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Nevus count, pigmentary characteristics, and melanoma-specific mortality among Norwegian women with melanoma >1.0 mm thick
Ahimbisibwe, A. Valberg, M. Green, Adèle C Ghiasvand, R. Rueegg, C. S. Rimal, R. Weiderpass, E. Sandanger, T. M. Robsahm, T. E. Veierød, M. B.
Ahimbisibwe, A.
Valberg, M.
Green, Adèle C
Ghiasvand, R.
Rueegg, C. S.
Rimal, R.
Weiderpass, E.
Sandanger, T. M.
Robsahm, T. E.
Veierød, M. B.
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Abstract
Little is known about if and how nevi and pigmentation are associated with melanoma-specific mortality. However, increased melanoma awareness in people with lighter pigmentation and many nevi may result in earlier diagnosis of thinner less-lethal tumors. The aim of this study was to investigate associations between nevus count (asymmetrical > 5 mm and small symmetrical), pigmentary characteristics (hair colour, eye colour, skin colour, freckling, pigmentary score), and melanoma-specific mortality in subjects with melanomas > 1 mm. Data from the Norwegian Women and Cancer cohort, established in 1991, with complete follow-up of melanoma patients until 2018 through the Cancer Registry of Norway, were used to estimate hazard ratios with 95% confidence intervals for the associations between nevus count, pigmentary characteristics, and melanoma-specific mortality, stratified by tumor thickness using Cox regression. Estimated hazard ratios consistently indicated a higher risk of melanoma death for those with darker vs lighter pigmentary characteristics in patients with tumors > 1.0-2.0 mm and > 2.0 mm thick (e.g. pigmentary score hazard ratio 1.25, 95% confidence interval (0.74-2.13)). Among women with melanomas > 1.0 mm thick, lighter pigmentation and asymmetrical nevi may be associated with lower melanoma-specific mortality, suggesting that factors that increase the risk of melanoma may also be associated with decreased risk of death from melanoma.
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2023
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Ahimbisibwe A, Valberg M, Green AC, Ghiasvand R, Rueegg CS, Rimal R, et al. Nevus Count, Pigmentary Characteristics, and Melanoma-specific Mortality among Norwegian Women with Melanoma >1.0 mm Thick. Acta Derm Venereol. 2023 Apr 4;103:adv4403. PubMed PMID: 37014267. Epub 2023/04/05. eng.