In vitro effects of recombinant human megakaryocyte growth and development factor on primary human tumour colony growth.
Lang, Shona H West, Catharine M L Jones, L Brooks, B Kasper, C De Wynter, Erika A Testa, Nydia G
Lang, Shona H
West, Catharine M L
Jones, L
Brooks, B
Kasper, C
De Wynter, Erika A
Testa, Nydia G
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Abstract
A study was made of the in vitro effects of recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) on breast, prostate, cervix and colon cancers. Tumour growth was assessed using a soft agar clonogenic assay. Stimulation of megakaryocyte numbers was seen in liquid culture following 10 ng/ml PEG-rHuMGDF. The same concentration led to no significant difference in colony-forming efficiencies for 22 of 25 tumour samples. A significant reduction in colony-forming efficiencies was seen for the remaining 3 specimens. These results suggest that PEG-rHuMGDF will not stimulate tumour growth in vivo.
Description
Date
1997
Publisher
Collections
Keywords
Breast Cancer
Colonic Cancer
Cancer
Prostatic Cancer
Cultured Tumour Cells
Uterine Cervical Cancer
Colonic Cancer
Cancer
Prostatic Cancer
Cultured Tumour Cells
Uterine Cervical Cancer
Type
Article
Citation
In vitro effects of recombinant human megakaryocyte growth and development factor on primary human tumour colony growth., 54 (2):141-5 Oncology