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Ifosfamide and mitomycin in combination for the treatment of patients with progressive advanced non-small cell lung cancer.
Gurney, H De Campos, E S Dodwell, David J Kamthan, A Thatcher, Nick
Gurney, H
De Campos, E S
Dodwell, David J
Kamthan, A
Thatcher, Nick
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Abstract
42 patients with progressive and advanced non-small cell lung cancer received chemotherapy comprising ifosfamide 1.5 g/m2, mesna 1.5 g/m2 and mitomycin 1.2 mg/m2 daily for 5 days. Only those patients with symptoms and progressive disease were selected for treatment. Partial response was achieved in 10/42 patients (23.8%) and stable disease in 25/42 (59.5%). The Karnofsky performance status (KP) improved in 10/42 patients (23.8%) and a subjective respiratory symptom score improved in 12 patients (28.6%). In addition 27 patients (64.3%) had stabilisation of both the KP and respiratory score following chemotherapy. These results indicate that the ifosfamide and mitomycin combination is active in non-small cell lung cancer in this selected group of patients with antitumour and symptom control activity.
Description
Date
1991
Publisher
Collections
Keywords
Lung Cancer
Cancer Metastasis
Cancer Metastasis
Type
Article
Citation
Ifosfamide and mitomycin in combination for the treatment of patients with progressive advanced non-small cell lung cancer. 1991, 27 (5):565-8 Eur. J. Cancer