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Untangling the tumorigenic role of homotrimeric collagen I

Jørgensen, Claus
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Abstract
Pancreatic ductal adenocarcinoma is characterized by a complex microenvironment. In this issue of Cancer Cell, Chen and colleagues define an oncogenic role of tumor-cell-produced collagen I homotrimers, wherein tumor development is promoted by integrin α3/β1-dependent activation of tumor cell signaling and modulation of tumor microbiome and immunity.
Authors
Jørgensen, Claus
Affiliation
Systems Oncology, Cancer Research UK Manchester Institute, University of Manchester, Alderley Park, Manchester, SK10 4TG, UK.
Description
Date
2022
Publisher
Collections
All Paterson Institute for Cancer Research
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Other
Citation
Jørgensen C. Untangling the tumorigenic role of homotrimeric collagen I. Cancer cell. 2022 Aug 8;40(8):802-4. PubMed PMID: 35944498. Epub 2022/08/10. eng.
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URI
http://hdl.handle.net/10541/625558
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