Deletion of a common region on the long arm of chromosome 6 in acute lymphoblastic leukaemia.
Menasce, Lia P Orphanos, Vassilis Santibanez-Koref, Mauro F Boyle, John M Harrison, Christine J
Menasce, Lia P
Orphanos, Vassilis
Santibanez-Koref, Mauro F
Boyle, John M
Harrison, Christine J
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Abstract
We have characterised a region of deletion on the long arm of chromosome 6 (6q) in six cases of acute lymphoblastic leukaemia, by fluorescence in situ hybridisation, using a series of YAC clones which map to 6q. Conventional cytogenetic analysis of four of these cases had been interpreted as showing terminal deletions of 6q. We demonstrated by FISH that in all cases the deletions were interstitial. D6S246 (6q16.3) was the only marker which was missing in all six cases, indicating a common region of deletion between the markers M6P1 at 6q14-15 and FYN at 6q21. Our results suggest the presence of a tumour suppressor gene within this interval.
Description
Date
1994-05
Publisher
Keywords
Precursor Cell Lymphoblastic Leukaemia-Lymphoma
Type
Article
Citation
Deletion of a common region on the long arm of chromosome 6 in acute lymphoblastic leukaemia. 1994, 10 (1):26-9 Genes Chromosomes Cancer