Loading...
A data-driven statistical model that estimates measurement uncertainty improves interpretation of ADC reproducibility: a multi-site study of liver metastases.
Pathak, Ryan Ragheb, Hossein Thacker, Neil A Morris, D Amiri, H Kuijer, J deSouza, N Heerschap, A Jackson, Alan
Pathak, Ryan
Ragheb, Hossein
Thacker, Neil A
Morris, D
Amiri, H
Kuijer, J
deSouza, N
Heerschap, A
Jackson, Alan
Citations
Altmetric:
Abstract
Apparent Diffusion Coefficient (ADC) is a potential quantitative imaging biomarker for tumour cell density and is widely used to detect early treatment changes in cancer therapy. We propose a strategy to improve confidence in the interpretation of measured changes in ADC using a data-driven model that describes sources of measurement error. Observed ADC is then standardised against this estimation of uncertainty for any given measurement. 20 patients were recruited prospectively and equitably across 4 sites, and scanned twice (test-retest) within 7 days. Repeatability measurements of defined regions (ROIs) of tumour and normal tissue were quantified as percentage change in mean ADC (test vs. re-test) and then standardised against an estimation of uncertainty. Multi-site reproducibility, (quantified as width of the 95% confidence bound between the lower confidence interval and higher confidence interval for all repeatability measurements), was compared before and after standardisation to the model. The 95% confidence interval width used to determine a statistically significant change reduced from 21.1 to 2.7% after standardisation. Small tumour volumes and respiratory motion were found to be important contributors to poor reproducibility. A look up chart has been provided for investigators who would like to estimate uncertainty from statistical error on individual ADC measurements.
Description
Date
2017-10-26
Publisher
Collections
Files
Loading...
s41598-017-14625-0.pdf
Adobe PDF, 1.85 MB
Keywords
Type
Article
Citation
A data-driven statistical model that estimates measurement uncertainty improves interpretation of ADC reproducibility: a multi-site study of liver metastases. 2017, 7 (1):14084 Sci Rep