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Dpb2 integrates the leading-strand DNA polymerase into the eukaryotic replisome.
Sengupta, Sugopa Van Deursen, Frederick de Piccoli, Giacomo Labib, Karim
Sengupta, Sugopa
Van Deursen, Frederick
de Piccoli, Giacomo
Labib, Karim
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Abstract
The eukaryotic replisome is a critical determinant of genome integrity with a complex structure that remains poorly characterized. A central unresolved issue is how the Cdc45-MCM-GINS helicase is linked to DNA polymerase epsilon, which synthesizes the leading strand at replication forks and is an important focus of regulation.
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Date
2013-04-08
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Article
Citation
Dpb2 integrates the leading-strand DNA polymerase into the eukaryotic replisome. 2013, 23 (7):543-52 Curr Biol