The frequency of osteolytic bone metastasis is determined by conditions of the soil, not the number of seeds; evidence from in vivo models of breast and prostate cancer.
Wang, N Reeves, Kimberley J Brown, H Fowles, A Docherty, F Ottewell, P Croucher, P Holen, I Eaton, C
Wang, N
Reeves, Kimberley J
Brown, H
Fowles, A
Docherty, F
Ottewell, P
Croucher, P
Holen, I
Eaton, C
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Abstract
While both preclinical and clinical studies suggest that the frequency of growing skeletal metastases is elevated in individuals with higher bone turnover, it is unclear whether this is a result of increased numbers of tumour cells arriving in active sites or of higher numbers of tumour cells being induced to divide by the bone micro-environment. Here we have investigated how the differences in bone turnover affect seeding of tumour cells and/or development of overt osteolytic bone metastasis using in vivo models of hormone-independent breast and prostate cancer.
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Date
2015
Publisher
Collections
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Type
Article
Citation
The frequency of osteolytic bone metastasis is determined by conditions of the soil, not the number of seeds; evidence from in vivo models of breast and prostate cancer. 2015, 34 (1):124 J Exp Clin Cancer Res