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Affective alterations in patients with Cushing's syndrome in remission are associated with decreased BDNF and cortisone levels.

Valassi, E
; 
Crespo, I
; 
Keevil, B
; 
Aulinas, A
; 
Urgell, E
; 
Santos, A
; 
Trainer, Peter J
; 
Webb, S
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Abstract
Affective alterations and poorer quality of life often persist in patients with Cushing's syndrome (CS) in remission. Brain-derived neurotrophic factor (BDNF) regulates the hypothalamic-pituitary-adrenal axis (HPA) and is highly expressed in brain areas controlling mood and response to stress. Our aims were to assess affective alterations after long-term remission of CS and evaluate whether they are associated with serum BDNF, salivary cortisol (SalF) and/or cortisone (SalE) concentrations.
Authors
Valassi, E
Crespo, I
Keevil, B
Aulinas, A
Urgell, E
Santos, A
Trainer, Peter J
Webb, S
Affiliation
Endocrinology/Medicine DepartmentHospital Sant Pau, Centro de Investigacion Biomedica en Red de Enfermedades Raras (CIBERER, Unidad 747), IIB-Sant Pau, ISCIII and Universitat Autonoma de Barcelona (UAB), Barcelona
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Date
2017-02
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All Christie Publications
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Article
Citation
Affective alterations in patients with Cushing's syndrome in remission are associated with decreased BDNF and cortisone levels. 2017, 176 (2):221-231 Eur J Endocrinol
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http://hdl.handle.net/10541/620078
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