The effect of itraconazole and rifampicin on the pharmacokinetics of osimertinib.
Vishwanathan, K Dickinson, P So, K Thomas, K Chen, Y de Castro Carpeno, J Dingemans, A Kim, H Kim, J Krebs, Matthew G
Vishwanathan, K
Dickinson, P
So, K
Thomas, K
Chen, Y
de Castro Carpeno, J
Dingemans, A
Kim, H
Kim, J
Krebs, Matthew G
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Abstract
We investigated the effects of a strong CYP3A4 inhibitor (itraconazole) or inducer (rifampicin) on the pharmacokinetics of the epidermal growth factor receptor kinase inhibitor osimertinib, in patients with advanced non-small cell lung cancer in two phase I, open-label, two-part clinical studies. Part one of both studies is reported.
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Date
2018-01-30
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Article
Citation
The effect of itraconazole and rifampicin on the pharmacokinetics of osimertinib. 2018, Br J Clin Pharmacol