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Sequential chemotherapy for advanced epithelial ovarian cancer: platinum combination cytoreduction followed by cyclophosphamide consolidation.
Lawton, Frank Blackledge, G Buckley, H Johnson, Richard J Kelly, K Crowther, Derek
Lawton, Frank
Blackledge, G
Buckley, H
Johnson, Richard J
Kelly, K
Crowther, Derek
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Abstract
Thirty-six women with advanced epithelial ovarian cancer were treated with a combination of cisplatin, vinblastine and bleomycin followed by a consolidation regimen of intravenous cyclophosphamide. There was a 53% response rate in previously untreated patients with 25% complete clinical remissions. Sixteen per cent of previously untreated patients remain in a complete clinical remission of greater than 3 yr duration. In a multivariate analysis bulk tumor residuum was not a significant adverse factor in terms of survival, suggesting that intensive chemical cytoreduction followed by non-cross-resistant consolidation may overcome such prognostic variables.
Description
Date
1985-12
Publisher
Collections
Keywords
Anticancerous Combined Chemotherapy Protocols
Ovarian Cancer
Ovarian Cancer
Type
Article
Citation
Sequential chemotherapy for advanced epithelial ovarian cancer: platinum combination cytoreduction followed by cyclophosphamide consolidation. 1985, 21 (12):1479-83 Eur J Cancer Clin Oncol