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Dual inhibition of STAT1 and STAT3 activation downregulates expression of PD-L1 in human breast cancer cells.

Sasidharan, Nair V
; 
Toor, S
; 
Ali, B
; 
Elkord, Eyad
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Abstract
Breast cancer is the most commonly diagnosed cancer, and it is a leading cause of cancer-related deaths in females worldwide. Triple-negative breast cancer (TNBC) constitutes 15% of breast cancer and shows distinct metastasis profiles with poor prognosis. Strong PD-L1 expression has been observed in some tumors, supporting their escape from immune surveillance. Targeting PD-L1 could be a promising therapeutic approach in breast cancer patients. We investigated potential molecular mechanisms for constitutive expression of PD-L1 by inhibiting upstream STAT1 and STAT3 signals.
Authors
Sasidharan, Nair V
Toor, S
Ali, B
Elkord, Eyad
Affiliation
Cancer Research Center , Qatar Biomedical Research Institute, College of Science and Engineering, Hamad Bin Khalifa University, Qatar Foundation , Doha , Qatar
Description
Date
2018-06
Publisher
Collections
All Paterson Institute for Cancer Research
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Type
Article
Citation
Dual inhibition of STAT1 and STAT3 activation downregulates expression of PD-L1 in human breast cancer cells. 2018, 22(6): 547-557 Expert Opin Ther Targets
Journal Title
Journal ISSN
Volume Title
URI
http://hdl.handle.net/10541/621040
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