Tamm-Horsfall protein is a marker of renal and extra-renal rhabdoid tumours.
Kumar, Shant Jakate, S M Marsden, Henry B Kumar, Patricia Jasani, B
Kumar, Shant
Jakate, S M
Marsden, Henry B
Kumar, Patricia
Jasani, B
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Abstract
A monoclonal antibody (MAb) to Tamm-Horsfall protein (THP) was used to stain 6 renal rhabdoid tumours (RRT) and 2 primary extra-renal rhabdoid tumours (E-RRT). One of the E-RRT was a tumour from the posterior fossa of a 3-year-old child and the other was a lump from the right side of the neck in an 18-month-old girl. Five of 6 RRT and both cases of E-RRT were positive for THP. Both cases of E-RRT also reacted with vimentin and cytokeratin MAbs. On electron microscopy, cells from both E-RRT were seen to contain concentric whorls of intermediate filaments characteristic of rhabdoid tumours. Viable tissues from one RRT and one E-RRT (the posterior fossa tumour) were available for tissue culture. Ninety-five percent of the cells growing out of both tumours were polygonal and approximately 5% of these cells were THP-positive.
Affiliation
Description
Date
1988-03-15
Publisher
Collections
Keywords
Head and Neck Cancer
Kidney Cancer
Cancer Proteins
Biological Tumour Markers
Kidney Cancer
Cancer Proteins
Biological Tumour Markers
Type
Article
Citation
Tamm-Horsfall protein is a marker of renal and extra-renal rhabdoid tumours. 1988, 41 (3):386-9 Int J Cancer