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Incidence of and survival after subsequent cancers in carriers of pathogenic MMR variants with previous cancer: a report from the prospective Lynch syndrome database.

Møller, P
; 
Seppälä, T
; 
Bernstein, I
; 
Holinski-Feder, E
; 
Sala, P
; 
Evans, D Gareth R
; 
Lindblom, A
; 
Macrae, F
; 
Blanco, I
; 
Sijmons, R
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Abstract
Today most patients with Lynch syndrome (LS) survive their first cancer. There is limited information on the incidences and outcome of subsequent cancers. The present study addresses three questions: (i) what is the cumulative incidence of a subsequent cancer; (ii) in which organs do subsequent cancers occur; and (iii) what is the survival following these cancers?
Authors
Møller, P
Seppälä, T
Bernstein, I
Holinski-Feder, E
Sala, P
Evans, D Gareth R
Lindblom, A
Macrae, F
Blanco, I
Sijmons, R
Jeffries, J
Vasen, H
Burn, J
Nakken, S
Hovig, E
Rødland, E
Tharmaratnam, K
de Vos Tot Nederveen Cappel, W
Hill, J
Wijnen, J
Jenkins, M
Green, K
Lalloo, F
Sunde, L
Mints, M
Bertario, L
Pineda, M
Navarro, M
Morak, M
Renkonen-Sinisalo, L
Frayling, I
Plazzer, J
Pylvanainen, K
Genuardi, M
Mecklin, J
Möslein, G
Sampson, J
Capella, G
Affiliation
Research Group Inherited Cancer, Department of Medical Genetics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
Description
Date
2016-06-03
Publisher
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All Christie Publications
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Article
Citation
Incidence of and survival after subsequent cancers in carriers of pathogenic MMR variants with previous cancer: a report from the prospective Lynch syndrome database. 2016: Gut
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http://hdl.handle.net/10541/618173
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