External-beam radiotherapy in T1-2 N0 penile carcinoma.
Azrif, Muhammad Logue, John P Swindell, Ric Wylie, James P Livsey, Jacqueline E
Azrif, Muhammad
Logue, John P
Swindell, Ric
Wylie, James P
Livsey, Jacqueline E
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Abstract
AIMS: To review the outcome of 41 patients with invasive carcinoma of the penis treated with external-beam radiotherapy using a consistent technique and dose. MATERIALS AND METHODS: Forty-one patients with carcinoma of the penis treated at Christie Hospital, Manchester, UK, between 1995 and 2000 were reviewed retrospectively. Radiotherapy was delivered using 4 MV linear accelerators with a dose of 50 Gy or 52.5 Gy in 16 fractions over 22 days. RESULTS: The distribution of patients according to stage was T1=37, T2=4, N0=40, N3=1. Median follow-up was 4.5 years. The local control rate was 62%, nodal relapse-free rate of 88%, relapse-free rate of 51% and overall survival of 88% at 5 years. All recurrences were salvaged by surgery. Penile ulceration occurred in 8% and urethral stenosis requiring dilatation in 29%. There were no penectomies for penile necrosis. CONCLUSION: EBXRT may be offered for T1-2 cancer of the penis with close surveillance to detect local recurrences early for salvage surgery without jeopardising overall survival. It remains an alternative option to penis-preserving surgery and should be discussed in a multidisciplinary setting and with the patient.
Description
Date
2006-05
Publisher
Collections
Keywords
Cancer Recurrence
Penile Cancer
Penile Cancer
Type
Article
Citation
External-beam radiotherapy in T1-2 N0 penile carcinoma. 2006, 18 (4):320-5 Clin Oncol (R Coll Radiol)