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DNA-DNA interstrand crosslinking by dimethyanesulphonic acid esters. Correlation with cytotoxicity and antitumour activity in the Yoshida lymphosarcoma model and relationship to chain length.
Bedford, Philip Fox, Brian W
Bedford, Philip
Fox, Brian W
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Abstract
Members of the homologous series of nine antitumour dimethanesulphonic acid esters, with the exception of ethylene dimethanesulphonate (EDMS), were found to cause DNA-DNA interstrand crosslinking in cells derived from the transplantable rodent Yoshida lymphosarcoma. The ability of the series to induce interstrand crosslinks was compared with in vitro cytotoxicity and in vivo antitumour activity and is discussed in relation to their chain length and ability to span critical target distances in DNA.
Authors
Bedford, Philip
Fox, Brian W
Fox, Brian W
Affiliation
Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester M20 9BX
Description
Date
1983-08-01
Publisher
Collections
Keywords
Type
Article
Citation
DNA-DNA interstrand crosslinking by dimethyanesulphonic acid esters. Correlation with cytotoxicity and antitumour activity in the Yoshida lymphosarcoma model and relationship to chain length. 1983, 32 (15):2297-301 Biochem Pharmacol