Standardization of procedures for ectopic marrow grafting. II. Influence on recipients of radiation dose and field size.
Molineux, Graham Schofield, Raymond Hendry, Jolyon H Testa, Nydia G
Molineux, Graham
Schofield, Raymond
Hendry, Jolyon H
Testa, Nydia G
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Abstract
The ectopic implantation of mouse marrow to the kidney capsule offers considerable scope as an assay of the hemopoietic microenvironment. Our previous work has shown that whole-body irradiation of the graft recipient prior to implantation results in superior ossicle formation in the kidney of the host. Here we report that a range of irradiation doses over a 4-Gy threshold are equivalent with respect to conditioning the graft recipient. We also show that two distinct and separable influences affect graft growth in the irradiated recipient, namely, a local effect brought about in the irradiated kidney (and restricted to it) and secondly, a systemic effect resulting from irradiation of sites other than the kidney, which nevertheless affects ossicle growth in the shielded renal capsule.
Affiliation
Description
Date
1987-07
Publisher
Collections
Keywords
Haematopoietic Stem Cells
Type
Article
Citation
Standardization of procedures for ectopic marrow grafting. II. Influence on recipients of radiation dose and field size. 1987, 15 (6):676-8 Exp. Hematol.