[18F]DPA-714: direct comparison with [11C]PK11195 in a model of cerebral ischemia in rats.
Boutin, H Prenant, C Maroy, R Galea, J Greenhalgh, A Smigova, A Cawthorne, C Julyan, Peter J Wilkinson, S Banister, S
Boutin, H
Prenant, C
Maroy, R
Galea, J
Greenhalgh, A
Smigova, A
Cawthorne, C
Julyan, Peter J
Wilkinson, S
Banister, S
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Abstract
Neuroinflammation is involved in several brain disorders and can be monitored through expression of the translocator protein 18 kDa (TSPO) on activated microglia. In recent years, several new PET radioligands for TSPO have been evaluated in disease models. [(18)F]DPA-714 is a TSPO radiotracer with great promise; however results vary between different experimental models of neuroinflammation. To further examine the potential of [(18)F]DPA-714, it was compared directly to [(11)C]PK11195 in experimental cerebral ischaemia in rats.
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Date
2013
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Article
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[18F]DPA-714: direct comparison with [11C]PK11195 in a model of cerebral ischemia in rats. 2013, 8 (2):e56441 PLoS ONE