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Large cell neuroendocrine lung carcinoma: consensus statement from The British Thoracic Oncology Group and the Association of Pulmonary Pathologists
Lindsay, Colin R Shaw, E. C. Moore, D. A. Rassl, D. Jamal-Hanjani, M. Steele, N. Naheed, S. Dick, C. Taylor, F. Adderley, Helen
Lindsay, Colin R
Shaw, E. C.
Moore, D. A.
Rassl, D.
Jamal-Hanjani, M.
Steele, N.
Naheed, S.
Dick, C.
Taylor, F.
Adderley, Helen
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Abstract
Over the past 10 years, lung cancer clinical and translational research has been characterised by exponential progress, exemplified by the introduction of molecularly targeted therapies, immunotherapy and chemo-immunotherapy combinations to stage III and IV non-small cell lung cancer. Along with squamous and small cell lung cancers, large cell neuroendocrine carcinoma (LCNEC) now represents an area of unmet need, particularly hampered by the lack of an encompassing pathological definition that can facilitate real-world and clinical trial progress. The steps we have proposed in this article represent an iterative and rational path forward towards clinical breakthroughs that can be modelled on success in other lung cancer pathologies.
Authors
Lindsay, Colin R
Shaw, E. C.
Moore, D. A.
Rassl, D.
Jamal-Hanjani, M.
Steele, N.
Naheed, S.
Dick, C.
Taylor, F.
Adderley, Helen
Black, F.
Summers, Yvonne J
Evans, M.
Rice, A.
Fabre, A.
Wallace, W. A.
Nicholson, S.
Haragan, A.
Taniere, P.
Nicholson, A. G.
Laing, G.
Cave, J.
Forster, M. D.
Blackhall, Fiona H
Gosney, J.
Popat, S.
Kerr, K. M.
Shaw, E. C.
Moore, D. A.
Rassl, D.
Jamal-Hanjani, M.
Steele, N.
Naheed, S.
Dick, C.
Taylor, F.
Adderley, Helen
Black, F.
Summers, Yvonne J
Evans, M.
Rice, A.
Fabre, A.
Wallace, W. A.
Nicholson, S.
Haragan, A.
Taniere, P.
Nicholson, A. G.
Laing, G.
Cave, J.
Forster, M. D.
Blackhall, Fiona H
Gosney, J.
Popat, S.
Kerr, K. M.
Description
Date
2021
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Article
Citation
Lindsay CR, Shaw EC, Moore DA, Rassl D, Jamal-Hanjani M, Steele N, et al. Large cell neuroendocrine lung carcinoma: consensus statement from The British Thoracic Oncology Group and the Association of Pulmonary Pathologists. Br J Cancer. 2021 Sep 6.