Publication

Three distinct subgroups of hypodiploidy in acute lymphoblastic leukaemia.

Harrison, Christine J
; 
Moorman, Anthony V
; 
Broadfield, Zoƫ J
; 
Cheung, Kan L
; 
Harris, Rachel L
; 
Reza Jalali, G
; 
Robinson, Hazel M
; 
Barber, Kerry E
; 
Richards, Susan M
; 
Mitchell, Christopher D
... show 10 more
Citations
Altmetric:
Abstract
This study of children and adults with acute lymphoblastic leukaemia (ALL) is the largest series of patients with hypodiploidy (<46 chromosomes) yet reported. The incidence of 5% was independent of age. Patients were subdivided by the number of chromosomes; near-haploidy (23-29 chromosomes), low hypodiploidy (33-39 chromosomes) and high hypodiploidy (42-45 chromosomes). The near-haploid and low hypodiploid groups were characterized by their chromosomal gains and a doubled hyperdiploid population. Structural abnormalities were more frequent in the low hypodiploid group. Near-haploidy was restricted to children of median age 7 years (range 2-15) whereas low hypodiploidy occurred in an older group of median age 15 years (range 9-54). Patients with 42-45 chromosomes were characterized by complex karyotypes involving chromosomes 7, 9 and 12. The features shared by the few patients with 42-44 chromosomes and the large number with 45 justified their inclusion in the same group. Survival analysis showed a poor outcome for the near-haploid and low hypodiploid groups compared to those with 42-45 chromosomes. Thus cytogenetics, or at least a clear definition of the modal chromosome number, is essential at diagnosis in order to stratify patients with hypodiploidy into the appropriate risk group for treatment.
Authors
Harrison, Christine J
Moorman, Anthony V
Broadfield, Zoƫ J
Cheung, Kan L
Harris, Rachel L
Reza Jalali, G
Robinson, Hazel M
Barber, Kerry E
Richards, Susan M
Mitchell, Christopher D
Eden, Tim O B
Hann, Ian M
Hill, Frank G H
Kinsey, Sally E
Gibson, Brenda E
Lilleyman, John S
Vora, Ajay J
Goldstone, Anthony H
Franklin, Ian M
Durrant, I Jill
Martineau, Mary
Affiliation
Leukaemia Research Fund Cytogenetics Group, Cancer Sciences Division, University of Southampton, Southampton, UK. harrison@soton.ac.uk
Description
Date
2004-06
Publisher
Collections
All Christie Publications
Show all metadata
Keywords
Leukaemia Lymphoma
Type
Article
Citation
Three distinct subgroups of hypodiploidy in acute lymphoblastic leukaemia. 2004, 125 (5):552-9 Br. J. Haematol.
Journal Title
Journal ISSN
Volume Title
URI
http://hdl.handle.net/10541/77838
Embedded videos