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Temozolomide in adult patients with advanced soft tissue sarcoma: a phase II study of the EORTC Soft Tissue and Bone Sarcoma Group.
Woll, Penella J Judson, I Lee, Siow Ming Rodenhuis, Sjoerd Nielsen, O S Buesa, J M Leyvraz, Serge Hermans, C Van Glabbeke, Martine M
Woll, Penella J
Judson, I
Lee, Siow Ming
Rodenhuis, Sjoerd
Nielsen, O S
Buesa, J M
Leyvraz, Serge
Hermans, C
Van Glabbeke, Martine M
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Abstract
Temozolomide, an oral imidazotetrazine derivative, was given to 31 patients with advanced soft tissue sarcoma. The dose of 750 mg/m2 was divided over 5 consecutive days, and escalated to 1000 mg/m2 over 5 days at cycle 2 if myelosuppression no worse than common toxicity criteria grade 2 was noted in the first 28-day cycle. A total of 99 treatment cycles were given to 31 patients. The drug was well tolerated, with nausea and vomiting as the most common side-effects. Only one partial tumour response was documented, giving a response rate of 3.33%, 95% confidence interval, (CI) 0.1-17.2%. The median time to progression was 8 weeks and the median survival was 27 weeks. These results indicate that temozolomide in this schedule is not active as second-line treatment in advanced soft tissue sarcoma.
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Date
1999-03
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Article
Citation
Temozolomide in adult patients with advanced soft tissue sarcoma: a phase II study of the EORTC Soft Tissue and Bone Sarcoma Group. 1999, 35 (3):410-2 Eur. J. Cancer