Modafinil for the treatment of fatigue in lung cancer: results of a placebo-controlled, double-blind, randomized trial.
Spathis, A Fife, K Blackhall, Fiona H Dutton, S Bahadori, R Wharton, R O'Brien, M Stone, P Benepal, T Bates, N
Spathis, A
Fife, K
Blackhall, Fiona H
Dutton, S
Bahadori, R
Wharton, R
O'Brien, M
Stone, P
Benepal, T
Bates, N
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Abstract
Fatigue is a distressing symptom occurring in more than 60% of patients with cancer. The CNS stimulants modafinil and methylphenidate are recommended for the treatment of cancer-related fatigue, despite a limited evidence base. We aimed to evaluate the efficacy and tolerability of modafinil in the management of fatigue in patients with non-small-cell lung cancer (NSCLC).
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Date
2014-04-28
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Article
Citation
Modafinil for the treatment of fatigue in lung cancer: results of a placebo-controlled, double-blind, randomized trial. 2014: J Clin Oncol