Antimitotic and cell growth inhibitory properties of combretastatin A-4-like ethers.
Lawrence, Nicholas J Rennison, David Woo, Meiki McGown, Alan T Hadfield, John A
Lawrence, Nicholas J
Rennison, David
Woo, Meiki
McGown, Alan T
Hadfield, John A
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Abstract
A series of diarylamines, diaryl and arylbenzyl ethers based on combretastatin A-4 was prepared and evaluated for anticancer activity. 2-Methoxy-5-(3',4',5'-trimethoxyphenoxymethyl)phenol was the most active (IC50, K562 20 nM) and caused significant G2/M cell cycle arrest.
Description
Date
2001-01-08
Publisher
Collections
Keywords
Cultured Tumour Cells
Type
Article
Citation
Antimitotic and cell growth inhibitory properties of combretastatin A-4-like ethers. 2001, 11 (1):51-4 Bioorg. Med. Chem. Lett.