Comparison of red and green light in the treatment of Bowen's disease by photodynamic therapy.
Morton, Colin A Whitehurst, Colin Moore, James V MacKie, Rona M
Morton, Colin A
Whitehurst, Colin
Moore, James V
MacKie, Rona M
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Abstract
BACKGROUND: A variety of protocols exist for the treatment of Bowen's disease by photodynamic therapy (PDT) using topical 5-aminolaevulinic acid (5-ALA). OBJECTIVE: To determine the optimal wavelength (red or green light) for this treatment. METHODS: A randomized comparison study of ALA-PDT using red (630 +/- 15 nm) or green (540 +/- 15 nm) light in the treatment of Bowen's disease. RESULTS: The initial clearance rate for lesions treated by red light was 94% (30 of 32) in comparison with 72% (21 of 29) for those lesions receiving green light (P = 0.002). Over the following 12 months, there were two recurrences in the red light group and seven in the green light group reducing the clearance rates to 88% and 48%, respectively. The frequency and severity of pain experienced were similar between the two treatment groups. No hyperthermia, nor significant difference in lesional temperatures, was observed between the wavelengths studied. CONCLUSION: Green light is less effective than red light, at a theoretically equivalent dose, in the treatment of Bowen's disease by topical ALA-PDT.
Description
Date
2000-10
Publisher
Collections
Keywords
Cancer Recurrence
Skin Cancer
Skin Cancer
Type
Article
Citation
Comparison of red and green light in the treatment of Bowen's disease by photodynamic therapy. 2000, 143 (4):767-72 Br. J. Dermatol.