Cytotoxic Michael-type amine adducts of alpha-methylene lactones alantolactone and isoalantolactone.
Lawrence, Nicholas J McGown, Alan T Nduka, Jane Hadfield, John A Pritchard, Robin G
Lawrence, Nicholas J
McGown, Alan T
Nduka, Jane
Hadfield, John A
Pritchard, Robin G
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Abstract
Two series of cytotoxic (IC50, K562 cell line, 1-24 microM) alpha-aminomethyl substituted lactones 3 and 4 were prepared by stereoselective Michael-type addition of amines to alantolactone (1) and isoalantolactone (2). The lactones 1 and 2 and their amine adducts induce apoptosis and act as alkylating agents.
Description
Date
2001-02-12
Publisher
Collections
Keywords
Cultured Tumour Cells
Type
Article
Citation
Cytotoxic Michael-type amine adducts of alpha-methylene lactones alantolactone and isoalantolactone. 2001, 11 (3):429-31 Bioorg. Med. Chem. Lett.