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Structural organisation and chromosomal mapping of the human Id-3 gene.
Deed, Richard W Hirose, Tohru Mitchell, Erika L D Santibanez-Koref, Mauro F Norton, John D
Deed, Richard W
Hirose, Tohru
Mitchell, Erika L D
Santibanez-Koref, Mauro F
Norton, John D
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Abstract
The helix-loop-helix (HLH) family of transcription factors plays a central role in the regulation of cell growth, differentiation and tumourigenesis. Members of the Id (inhibitor of DNA binding) class of these nuclear proteins are able to heterodimerise with and thereby antagonise the functions of other transcription factors of this family. We report here on the genomic organisation of the human Id3 (HLH 1R21/heir1) gene. Comparison with the two other mammalian Id genes, Id1 and Id2, reveals a highly conserved protein coding gene organisation consistent with evolution from a common, ancestral Id-like gene. In addition, by using a yeast artificial chromosome (YAC) clone of Id3, we have fine-scale mapped the gene to chromosome band 1p36.1 by fluorescence in situ hybridisation (FISH) and, using the same FISH technique, we have detected heterogeneity in tumour-associated 1p36 chromosome translocations.
Description
Date
1994-12-30
Publisher
Collections
Keywords
Breast Cancer
Lung Cancer
Cancer Proteins
Cultured Tumour Cells
Leukaemia
Lung Cancer
Cancer Proteins
Cultured Tumour Cells
Leukaemia
Type
Article
Citation
Structural organisation and chromosomal mapping of the human Id-3 gene. 1994, 151 (1-2):309-14 Gene