%PDF-1.5
%
215 0 obj
<>
endobj
205 0 obj
<>
endobj
204 0 obj
<>stream
2016-06-02T21:12:24+05:30
Arbortext Advanced Print Publisher 10.0.1465/W Unicode
2016-10-20T06:04:06-07:00
2016-10-20T06:04:06-07:00
Acrobat Distiller 8.1.0 (Windows)
application/pdf
Incidence of and survival after subsequent cancers in carriers of pathogenic MMR variants with previous cancer: a report from the prospective Lynch syndrome database
uuid:b0749eed-e70a-4227-975e-42456eb48c11
uuid:6ea7bd31-1dd2-11b2-0a00-1e00a8a6d7ff
endstream
endobj
216 0 obj
<>
endobj
150 0 obj
<>
endobj
202 0 obj
<>
endobj
5 0 obj
<>
endobj
201 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/Properties<>>>/Rotate 0/Thumb 166 0 R/Type/Page>>
endobj
1 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]>>/Rotate 0/Thumb 2 0 R/Type/Page>>
endobj
37 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]>>/Rotate 0/Thumb 38 0 R/Type/Page>>
endobj
54 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]>>/Rotate 0/Thumb 55 0 R/Type/Page>>
endobj
62 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]>>/Rotate 0/Thumb 63 0 R/Type/Page>>
endobj
80 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/Rotate 0/Thumb 81 0 R/Type/Page>>
endobj
97 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/Rotate 0/Thumb 98 0 R/Type/Page>>
endobj
104 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]>>/Rotate 0/Thumb 105 0 R/Type/Page>>
endobj
288 0 obj
<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/Type/Page>>
endobj
289 0 obj
<>/ProcSet[/PDF/Text]>>/Type/Page>>
endobj
330 0 obj
[332 0 R 333 0 R 334 0 R 335 0 R 336 0 R]
endobj
331 0 obj
<>stream
84 739 m
511 739 l
0 0 m
S
BT
ET
BT
/T1_0 1 Tf
12 0 0 12 84 718 Tm
(Notes)Tj
ET
84 182 m
511 182 l
0 0 m
S
BT
ET
BT
0 0 1 rg
/T1_0 1 Tf
10 0 0 10 84 143.99997 Tm
(http://group.bmj.com/group/rights-licensing/permissions)Tj
0 g
/T1_1 1 Tf
0 1 TD
(To request permissions go to:)Tj
ET
BT
0 0 1 rg
/T1_0 1 Tf
10 0 0 10 84 109.99997 Tm
(http://journals.bmj.com/cgi/reprintform)Tj
0 g
/T1_1 1 Tf
T*
(To order reprints go to:)Tj
ET
BT
0 0 1 rg
/T1_0 1 Tf
10 0 0 10 84 75.99997 Tm
(http://group.bmj.com/subscribe/)Tj
0 g
/T1_1 1 Tf
T*
(To subscribe to BMJ go to:)Tj
ET
BT
0 0 1 rg
/T1_1 1 Tf
8 0 0 8 401.55591 780 Tm
(group.bmj.com)Tj
0 g
-16.28699 0 Td
( on October 20, 2016 - Published by )Tj
0 0 1 rg
-8.22598 0 Td
(http://gut.bmj.com/)Tj
0 g
-8.11398 0 Td
(Downloaded from )Tj
ET
endstream
endobj
327 0 obj
<>
endobj
296 0 obj
<>
endobj
332 0 obj
<>
endobj
333 0 obj
<>
endobj
334 0 obj
<>
endobj
335 0 obj
<>
endobj
336 0 obj
<>
endobj
341 0 obj
<>
endobj
340 0 obj
<>
endobj
339 0 obj
<>
endobj
338 0 obj
<>
endobj
337 0 obj
<>
endobj
325 0 obj
[342 0 R 343 0 R 344 0 R 345 0 R 346 0 R 347 0 R 348 0 R 349 0 R 350 0 R 351 0 R 352 0 R 353 0 R 354 0 R]
endobj
326 0 obj
<>stream
q
61.5 0 0 38.75 103.25 714.25 cm
/Im0 Do
Q
BT
/T1_0 1 Tf
15 0 0 15 184 692.99991 Tm
(the prospective Lynch syndrome database)Tj
0 1 TD
(variants with previous cancer: a report from)Tj
T*
(cancers in carriers of pathogenic MMR )Tj
0 1.00001 TD
(Incidence of and survival after subsequent)Tj
ET
BT
/T1_1 1 Tf
10 0 0 10 184 578.99969 Tm
(\))Tj
0 1 TD
(Sampson, Gabriel Capella and in collaboration with The Mallorca Group \(\
)Tj
0 1.00001 TD
(Maurizio Genuardi, Jukka-Pekka Mecklin, Gabriela M\366slein, Julian R )Tj
26.73098 1 Td
(Pylvanainen,)Tj
-26.73098 0 Td
(Renkonen-Sinisalo, Ian M Frayling, John-Paul Plazzer, Kirsi )Tj
0 1 TD
(Bertario, Marta Pineda, Matilde Navarro, Monika Morak, Laura)Tj
0 1.00001 TD
(Jenkins, Kate Green, Fiona Lalloo, Lone Sunde, Miriam Mints, Lucio )Tj
0 1 TD
(Wouter H de Vos tot Nederveen Cappel, James Hill, Juul Wijnen, Mark)Tj
T*
(Eivind Hovig, Einar Andreas R\370dland, Kukatharmini Tharmaratnam, )Tj
T*
(Rolf Sijmons, Jacqueline Jeffries, Hans Vasen, John Burn, Sigve Nakken,)Tj
0 1.00001 TD
(Sala, D Gareth Evans, Annika Lindblom, Finlay Macrae, Ignacio Blanco, )Tj
0 1 TD
(P\345l M\370ller, Toni Sepp\344l\344, Inge Bernstein, Elke Holinski-Fede\
r, Paola)Tj
ET
BT
/T1_1 1 Tf
10 0 0 10 202.90002 555 Tm
( published online June 3, 2016)Tj
/T1_2 1 Tf
-1.89 0 Td
(Gut\240)Tj
ET
84 541 m
511 541 l
0 0 m
S
BT
ET
BT
/T1_1 1 Tf
10 0 0 10 481.3186 506.99997 Tm
( )Tj
0 0 1 rg
/T1_0 1 Tf
-29.73186 0 Td
(http://gut.bmj.com/content/early/2016/06/03/gutjnl-2016-311403)Tj
0 g
/T1_1 1 Tf
T*
(Updated information and services can be found at: )Tj
ET
84 493 m
511 493 l
0 0 m
S
BT
ET
BT
/T1_2 1 Tf
10 0 0 10 184 465 Tm
(These include:)Tj
ET
BT
/T1_0 1 Tf
12 0 0 12 125.31604 432.99997 Tm
(Material)Tj
-3.16699 1 Td
(Supplementary)Tj
ET
BT
/T1_1 1 Tf
10 0 0 10 205.10995 426.99994 Tm
( )Tj
0 0 1 rg
/T1_0 1 Tf
-2.111 0 Td
(html)Tj
T*
(http://gut.bmj.com/content/suppl/2016/06/03/gutjnl-2016-311403.DC1.)Tj
0 g
/T1_1 1 Tf
0 1.00001 TD
(Supplementary material can be found at: )Tj
ET
BT
/T1_0 1 Tf
12 0 0 12 99.30817 407 Tm
(References)Tj
ET
BT
0 0 1 rg
/T1_1 1 Tf
10 0 0 10 481.3186 398.99997 Tm
(#BIBL)Tj
/T1_0 1 Tf
-29.73186 0 Td
(http://gut.bmj.com/content/early/2016/06/03/gutjnl-2016-311403)Tj
0 g
/T1_1 1 Tf
0 1 TD
(This article cites 7 articles, 3 of which you can access for free at: )Tj
ET
BT
/T1_0 1 Tf
12 0 0 12 87.96826 369 Tm
(Open Access)Tj
ET
BT
0 0 1 rg
/T1_1 1 Tf
10 0 0 10 286.80978 320.99985 Tm
(http://creativecommons.org/licenses/by-nc/4.0/)Tj
0 g
-10.28098 0 Td
(non-commercial. See: )Tj
T*
(provided the original work is properly cited and the use is)Tj
0 1.00001 TD
(non-commercially, and license their derivative works on different terms,\
)Tj
0 1 TD
(permits others to distribute, remix, adapt, build upon this work)Tj
T*
(Commons Attribution Non Commercial \(CC BY-NC 4.0\) license, which )Tj
0 1.00001 TD
(This is an Open Access article distributed in accordance with the Creati\
ve)Tj
ET
BT
/T1_0 1 Tf
12 0 0 12 119.29999 288.99997 Tm
(service)Tj
-2.83299 1 Td
(Email alerting)Tj
ET
BT
/T1_1 1 Tf
10 0 0 10 184 292.99997 Tm
(box at the top right corner of the online article. )Tj
0 1 TD
(Receive free email alerts when new articles cite this article. Sign up i\
n the)Tj
ET
84 266 m
511 266 l
0 0 m
S
BT
ET
BT
/T1_0 1 Tf
12 0 0 12 95.98444 227.99997 Tm
(Collections)Tj
3.00099 1 Td
(Topic)Tj
ET
BT
/T1_1 1 Tf
10 0 0 10 184 242 Tm
(Articles on similar topics can be found in the following collections )Tj
ET
BT
/T1_1 1 Tf
10 0 0 10 306.81985 202.99994 Tm
( \(1946\))Tj
0 0 1 rg
-11.28199 0 Td
(Pancreas and biliary tract)Tj
0 g
5.891 1 Td
( \(1540\))Tj
0 0 1 rg
-5.891 0 Td
(Colon cancer)Tj
0 g
5.83601 1.00001 Td
( \(303\))Tj
0 0 1 rg
-5.83601 0 Td
(Open access)Tj
ET
84 182 m
511 182 l
0 0 m
S
BT
ET
BT
/T1_0 1 Tf
10 0 0 10 84 143.99997 Tm
(http://group.bmj.com/group/rights-licensing/permissions)Tj
0 g
/T1_1 1 Tf
T*
(To request permissions go to:)Tj
ET
BT
0 0 1 rg
/T1_0 1 Tf
10 0 0 10 84 109.99997 Tm
(http://journals.bmj.com/cgi/reprintform)Tj
0 g
/T1_1 1 Tf
T*
(To order reprints go to:)Tj
ET
BT
0 0 1 rg
/T1_0 1 Tf
10 0 0 10 84 75.99997 Tm
(http://group.bmj.com/subscribe/)Tj
0 g
/T1_1 1 Tf
T*
(To subscribe to BMJ go to:)Tj
ET
BT
0 0 1 rg
/T1_1 1 Tf
8 0 0 8 401.55591 780 Tm
(group.bmj.com)Tj
0 g
-16.28699 0 Td
( on October 20, 2016 - Published by )Tj
0 0 1 rg
-8.22598 0 Td
(http://gut.bmj.com/)Tj
0 g
-8.11398 0 Td
(Downloaded from )Tj
ET
endstream
endobj
329 0 obj
<>/Filter/FlateDecode/Height 155/Length 5344/Name/X/Subtype/Image/Type/XObject/Width 246>>stream
H TGǙ{Bq
^&BDQ2J<7}D\VWLq%DcAq= qE<0xD4"=ݽtq}?S뚯|" @D,
06`8 lp@ူa
06`8 lp@ူa
06`8 lp@ူa
06`8 lp@ူaFβ[yH$$`1#zH[L(wVʜJL.aITZGRze2L"ޣ9#*hk %MW][wh-R.JqiYVWUqtP'vh1^1ûrJ\x5\! 5R
zAؐS6y~6VKz̉
=t9/V6qVX vm8fQ8WI<=ܬ=C]B.z{VF8aIN vd8*}Yvײ>-DO3WnTU[)!;x4S3C&dj
dx8Vt}Ҭ7pۿuq~SPҒ蠖Ib/8\Azωj?zR-8Q|S04ざ0=&ߛ{p~mt|**'y-4+֒3?܆YǮ$}[UA/ nlPߎ-1@j{^JVc\0#P7upᨺ2a?Zd؞稔KQަy]Goմإ:saO 07 Uoeu1=f^gTWcd jS%|ۤ&E\{{J(}FGL?`8n ڔycֽhfV5<-o_QlwY)79apZݵc&z*rt7a7:Ͱ2^Og(M{ҍ*р^770t۽ HAy,@ʨ!ɻϜ*D
v9QI'SzzܒJ*1ahp0T;c_MNTD'7*ЗC!p0Z[[rtoj< Q8o]PjͰ#|sXH@_b3JףQ[
3pSN*#`80\&ٷ:ګm3