The Christie Research Publications Repository

The repository contains the research outputs from staff and students at The Christie NHS Foundation Trust and Cancer Research UK Manchester Institute.

Current Repository Content:

Over 7000 peer reviewed articles, reviews and selected publications from 1933 onwards.

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We upload data monthly to the repository. To find out more about the repository, article submission or for advice on how to search it:

Please contact Kostoris Library on 0161 446 3456/3455.

Recent Submissions

  • PersonMetadata only
    Dan, Anderson
  • PublicationOpen Access
    CT- and MR-based image-based data mining are consistent in the brain
    (2024) Wilson, L. J.; Davey, Angela; Vasquez Osorio, Eliana; Faught, A. M.; Green, Andrew; Bulbeck, H.; Thomson, A.; Goddard, J.; McCabe, Martin G; Merchant, T. E.; van Herk, Marcel; Aznar, Mmrianne C; Division of Cancer Sciences, Faculty of Biology Medicine and Health, The University of Manchester, Manchester, UK; The Christie NHS Foundation Trust, Manchester, UK.
    PURPOSE: Image-based data mining (IBDM) is a voxel-based analysis technique to investigate dose-response. Most often, IBDM uses radiotherapy planning CTs because of their broad accessibility, however, it was unknown whether CT provided sufficient soft tissue contrast for brain IBDM. This study evaluates whether MR-based IBDM improves upon CT-based IBDM for studies of children with brain tumours. METHODS: We compared IBDM pipelines using either CT- or MRI-based spatial normalisation in 128 children (ages 3.3-19.7 years) who received photon radiotherapy for primary brain tumours at a single institution. We quantified spatial-normalisation accuracy using contour comparison measures (centre-of-mass separation, average contour distance-to-agreement (DT(avg)), and Hausdorff distance) at multiple anatomic loci. We performed an end-to-end test of CT- and MRI-IBDM using modified clinical dose distributions and simulated effect labels to detect associations in pre-defined anatomic loci. Accuracy was assessed via sensitivity and specificity. RESULTS: Spatial normalisation accuracy was comparable for both modalities, with a significant but small improvement for MRI compared to CT in all structures except the brainstem. The median (range) difference between the DT(avg) for the two pipelines was 0.37 (0.00-2.91) mm. The end-to-end test revealed no significant difference in sensitivity of the IBDM-identified regions for the two pipelines. Specificity slightly improved for MR-IBDM at the 99% significance level. CONCLUSION: CT-based IBDM was comparable to MR-based IBDM, despite a small advantage in spatial normalisation accuracy with MRI. The use of CT-IBDM over MR-IBDM is useful for multi-institutional retrospective IBDM studies, where the availability of standardised MRI data can be limited.
  • PublicationOpen Access
    Neurofibromatosis type 2 presenting as symptomatic gallbladder hydrops: a rare case report and literature review
    (2024) Hafez, B.; Alwan, J. S.; El Hout, Walid; Koussa, K.; El Annan, T.; Noun, D.; Zaghal, A.; The Christie NHS Foundation Trust, Manchester, United Kingdom
  • PublicationMetadata only
    Radiation dose fractionations for malignants spinal cord compression in patients not eligible for surgery: a systematic review and network meta-analysis of randomized controlled trials
    (2024) Wong, H. C. Y.; Santos, M. D. C.; Leung, S.; Wong, K. N. E.; Chan, S.; Caini, S.; Hoskin, Peter; Maranzano, E.; Dearnaley, D.; Lee, S. F.; Chan, A. W.; Marta, G. N.; Choi, I. J.; Simone, C. B.; Raman, S.; Oldenburger, E.; Rembielak, Anna; Khan, L.; Chow, E.; Rades, D.; Division of Cancer Sciences, University of Manchester, Manchester, United Kingdom; The Christie NHS Foundation Trust, Manchester, United Kingdom
  • PublicationMetadata only
    GEC-ESTRO recommendations for head & neck cancer brachytherapy (interventional radiotherapy): 2nd update with focus on HDR and PDR
    (2024) Guinot, J. L.; Bacorro, W.; Budrukkar, A.; Bussu, F.; Gonzalez-Perez, V.; Jaberi, R.; Martinez-Monge, R.; Rembielak, Anna; Rovirosa, A; Strnad, V.; Takácsi-Nagy, Z.; Tagliaferri, L.; Department of Clinical Oncology, The Christie NHS Foundation Trust, Manchester, United Kingdom; Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, United Kingdom.
    Modern brachytherapy (BT) is playing an important role in the multidisciplinary treatment of Head and Neck (H&N) cancer, as an organ- and function-preserving therapy. Low-dose-rate (LDR) technology has been replaced by modern remote afterloading and stepping source equipment using pulsed dose rate (PDR) or high dose rate (HDR) sources, improved image guidance and 3D treatment planning systems. This is an update of the previous GEC-ESTRO recommendations for H&N tumors, mainly applied to squamous carcinomas. Indications, results and recommended doses for different tumor sites are presented according to the published studies.
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