The Christie Research Publications Repository

The repository contains the research outputs from staff and students at The Christie NHS Foundation Trust and Cancer Research UK Manchester Institute.

Current Repository Content:

Over 7000 peer reviewed articles, reviews and selected publications from 1933 onwards.

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We upload data monthly to the repository. To find out more about the repository, article submission or for advice on how to search it:

Please contact Kostoris Library on 0161 446 3456/3455.

Recent Submissions

  • ItemMetadata only
    New systemic treatment paradigms in advanced biliary tract cancer and variations in patient access across Europe (vol 50, 101170, 2025)
    (2025) Rimassa, L.; Lamarca, A.; O'Kane, G. M.; Edeline, J.; McNamara, M. G.; Vogel, A.; Fassan, M.; Forner, A.; Kendall, T.; Adeva, J.; Casadei-Gardini, A.; Fornaro, L.; Hollebecque, A.; Lowery, M. A.; Macarulla, T.; Malka, D.; Mariamidze, E.; Niger, M.; Ustav, A.; Bridgewater, J.; Macias, R. I. R.; Braconi, C.; Humanitas Univ, Dept Biomed Sci, Via Rita Levi Montalcini 4, I-20072 Pieve Emanuele, Milan, Italy IRCCS Humanitas Res Hosp, Humanitas Canc Ctr, Med Oncol & Hematol Unit, Via A Manzoni 56, I-20089 Milan, Italy Fdn Jimenez Diaz Univ Hosp, Inst Invest Sanitaria Fdn Jimenez Diaz, Oncohlth Inst, Dept Med Oncol, Avda Reyes Catolicos 2, Madrid 28040, Spain Univ Coll Dublin, Belfield, Dublin, Ireland St Vincents Univ Hosp, Dept Med Oncol, Elm Pk, Dublin, Ireland Univ Rennes, Dept Med Oncol, INSERM, COSS Chem Oncogenesis Stress Signaling,CLCC Eugene, F-35000 Rennes, France Univ Manchester, Div Canc Sci, Manchester M20 4BX, England Christie NHS Fdn Trust, Dept Med Oncol, Manchester M20 4BX, England Toronto Gen Hosp, UHN, 200 Elizabeth St, Toronto, ON M5G 2C4, Canada Princess Margaret Canc Ctr, 610 Univ Ave, Toronto, ON M5G 2M9, Canada Hannover Med Sch, Carl Neuberg Str 1, D-30659 Hannover, Germany Veneto Inst Oncol IOV IRCCS, Via Gattamelata 64, I-35128 Padua, Italy Univ Barcelona, Barcelona Clin Liver Canc BCLC Grp, Liver Unit, Hosp Clin,IDIBAPS,ICMDM, Villarroel 170, Barcelona 08036, Spain Ctr Invest Biomed Red Enfermedades Hepat & Digest, Ave Monforte de Lemos 3-5, Madrid 28029, Spain Univ Edinburgh, Inst Regenerat & Repair, Ctr Inflammat Res, 5 Little France Dr, Edinburgh EH16 4UU, Scotland Univ Edinburgh, Edinburgh Pathol, 51 Little France Crescent, Edinburgh EH16 4SA, Scotland CRUK Scotland Canc Ctr, Switchback Rd, Glasgow G61 1BD, Scotland Hosp Univ 12 Octubre, Dept Med Oncol, Ave Cordoba s-n, Usera 28041, Madrid, Spain Univ Vita Salute San Raffaele, IRCCS San Raffaele Sci Inst Hosp, Dept Oncol, Via Olgettina 60, I-20132 Milan, Italy Azienda Osped Univ Pisana, Med Oncol Unit 2, Via Roma 67, I-56126 Pisa, Italy Gustave Roussy, Dept Med Oncol, 114 Rue Edouard Vaillant, F-94805 Villejuif, France Trinity Coll Dublin, Trinity St James Canc Inst, Dublin, Ireland Vall dHebron Univ Hosp, Vall dHebron Inst Oncol VHIO, Ctr Cellex, Carrer Natzaret 115-117, Barcelona 08035, Spain Inst Mutualiste Montsouris, Dept Med Oncol, 42 Blvd Jourdan, F-75014 Paris, France Todua Clin, Dept Oncol & Hematol, Tevdore Mgvdeli 13, Tbilisi 0112, Georgia Fdn IRCCS Ist Nazl Tumori Milano, Med Oncol Dept, Via Venezian 1, I-20133 Milan, Italy North Estonian Med Ctr, Clin Oncol, Sytiste Rd 19, EE-13419 Tallinn, Estonia UCL Canc Inst, 72 Huntley St, London WC1E 6DD, England Univ Salamanca, Expt Hepatol & Drug Targeting HEVEPHARM Grp, IBSAL, CIBERehd, Campus M Unamuno S N, Salamanca 37007, Spain Univ Glasgow, Sch Canc Sci, Switchback Rd, Glasgow G61 1QH, Scotland Beatson West Scotland Canc Ctr, 1053 Great Western Rd, Glasgow G12 0YN, Scotland
  • ItemMetadata only
    Priority outcomes of pelvic exenteration for rectal cancer: a patient, carer, and clinician consensus
    (2024) Brown, K. G. M.; Morkaya, J.; Solomon, M. J.; Ng, K. S.; White, K.; Sutton, P.; Winter, D. C.; Steffens, D.; Department of Colorectal Surgery, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia. Surgical Outcomes Research Centre (SOuRCe), Royal Prince Alfred Hospital, Sydney, New South Wales, Australia. Institute of Academic Surgery (IAS), Royal Prince Alfred Hospital, Sydney, New South Wales, Australia. Faculty of Medicine and Health, Central Clinical School, University of Sydney, Sydney, New South Wales, Australia. Sydney Nursing School, University of Sydney, Sydney, New South Wales, Australia. The Daffodil Centre, University of Sydney, a joint venture with Cancer Council NSW, Sydney, New South Wales, Australia. Colorectal and Peritoneal Oncology Centre, The Christie NHS Foundation Trust, Manchester, UK. Division of Cancer Sciences, University of Manchester, Manchester, UK. Department of Surgery, St Vincent's University Hospital, Dublin, Ireland.
  • ItemMetadata only
    Proton therapy for vestibular schwannomas
    (2025) Whitfield, G. A.; Burnet, N. G.; Clinical Oncology, Christie NHS Foundation Trust, Manchester, United Kingdom. Electronic address: gwhitfield@nhs.net. Clinical Oncology, Christie NHS Foundation Trust, Manchester, United Kingdom.
    This chapter discusses the treatment of vestibular schwannoma using proton beam therapy (PBT), which has been used in stereotactic radiosurgery, hypofractionated stereotactic radiotherapy, and fully fractionated radiotherapy. Using PBT, almost no dose is delivered beyond the proton Bragg peak, so compared to photon therapy the integral dose is reduced and less dose may be delivered to specific normal tissues, which may, in turn, reduce some acute and/or late toxicities. In PBT, however, there are additional uncertainties, including range uncertainty, which requires a larger 'safety margin' than is typically required for photon radiosurgery or hypofractionated stereotactic radiotherapy. The few published PBT series that describe patient outcomes are presented, all retrospective single center series, which do not suggest that local control or cranial nerve toxicity is more favorable than with photon therapy. Other toxicities, such as neurocognitive outcomes, risk of stroke, and radiation-induced malignancies, cannot be evaluated from the limited data. However, these series largely reflect now outdated treatment planning and delivery methods and do not include the latest Pencil Beam Scanning technology. It remains to be established whether outcomes with modern state-of-the-art PBT may be more favorable and whether particular subgroups, such as pediatric and young adult patients, may benefit.
  • ItemMetadata only
    Outcomes of Complex Circumcisions for Pre-cancerous and Cancerous Penile Lesions at a Tertiary Referral Centre: A Retrospective Cohort Study
    (2025) Elmousili, M.; Kafagi, A. H.; Abdullah, M.; Christopoulos, P.; Lau, M.; Parnham, A.; Sangar, V.; Department of Urology, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester, GBR. Department of Urology, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, GBR. Department of Urology, The Christie Hospital, The Christie NHS Foundation Trust, Manchester, GBR.
    OBJECTIVE: This study aimed to evaluate the complication rates of complex circumcisions performed for penile cancer, penile intra-epithelial neoplasia (PeIN) and severe lichen sclerosus, and to identify any predictors of post-operative complications. PATIENTS AND METHODS: A retrospective cohort study was conducted at a tertiary urology referral centre. Records of 191 male patients who underwent complex circumcisions between 2014 and 2020 were reviewed. Complex circumcision was defined as circumcision for cancerous or pre-cancerous lesions, condyloma or severe lichen sclerosus with >50% adherence to the glans. Patient demographics, indications, surgical variables and complications were analysed. Complications were graded using the Clavien-Dindo classification. RESULTS: The overall complication rate was 11%. The most common complications were infection (n = 5) and altered glans sensation (n = 5). Consultant-performed procedures had a significantly higher complication rate (14%) compared to those performed by trainees (2.3%) (p = 0.05), likely reflecting case complexity. No statistically significant associations were found between complications and patient age, indication, cancer stage or grade, type of circumcision or suture technique. All complications were Clavien-Dindo Grade I or II, and there were no readmissions. CONCLUSION: Complex adult circumcisions carry a modest complication risk, particularly in oncological cases. While consultant-led procedures had higher complication rates, this likely reflects the referral of more complex pathology. These findings provide a UK-based evidence base for consenting patients undergoing circumcision for malignant or pre-malignant indications.
  • ItemMetadata only
    Plain language summary: tarlatamab for patients with previously treated small cell lung cancer
    (2024) Ahn, M. J.; Cho, B. C.; Felip, E.; Korantzis, I.; Ohashi, K.; Majem, M.; Juan-Vidal, O.; Handzhiev, S.; Izumi, H.; Lee, J. S.; Dziadziuszko, R.; Wolf, J.; Blackhall, F.; Reck, M.; Alvarez, J. B.; Hummel, H. D.; Dingemans, A. M. C.; Sands, J.; Akamatsu, H.; Owonikoko, T. K.; Ramalingam, S. S.; Borghaei, H.; Johnson, M. L.; Huang, S.; Mukherjee, S.; Minocha, M.; Jiang, T.; Martinez, P.; Anderson, E. S.; Paz-Ares, L.; Sungkyunkwan Univ, Samsung Med Ctr, Sch Med, Seoul, South Korea Yonsei Univ, Yonsei Canc Ctr, Coll Med, Seoul, South Korea Vall dHebron Univ Hosp, Barcelona, Spain Vall dHebron Inst Oncol, Barcelona, Spain St Loukas Hosp, Dept Med Oncol, Thessaloniki, Greece Okayama Univ Hosp, Dept Resp Med, Okayama, Japan Hosp Santa Creu & Sant Pau, Barcelona, Spain Hosp Univ & Politecn La Fe, Valencia, Spain Univ Klinikum Krems, Klin Abt Pneumol, Krems, Austria Natl Canc Ctr Hosp East, Dept Thorac Oncol, Kashiwa, Chiba, Japan Seoul Natl Univ, Bundang Hosp, Seongnam, South Korea Med Univ Gdansk, Dept Oncol & Radiotherapy, Gdansk, Poland Med Univ Gdansk, Early Phase Clin Trials Ctr, Gdansk, Poland Univ Hosp Cologne, Dept Internal Med, Ctr Integrated Oncol, Cologne, Germany Christie NHS Fdn Trust, Manchester, Lancs, England Univ Manchester, Manchester, Lancs, England German Ctr Lung Res, Airway Res Ctr North, Lungen Clin, Grosshansdorf, Germany West Virginia Univ, Hlth Sci Ctr, Morgantown, WV 26506 USA Univ Klinikum Wurzburg, Comprehens Canc Ctr Mainfranken, Translat Oncol Early Clin Trial Unit, Wurzburg, Germany Univ Klinikum Wurzburg, Bavarian Canc Res Ctr, Wurzburg, Germany Erasmus MC, Dept Pulm Med, Canc Inst, Rotterdam, Netherlands Harvard Med Sch, Dana Farber Canc Inst, Boston, MA 02115 USA Wakayama Med Univ Hosp, Wakayama, Japan Univ Pittsburgh, Med Ctr, Hillman Canc Ctr, Div Hematol Oncol, Pittsburgh, PA USA Emory Univ, Winship Canc Inst, Atlanta, GA 30322 USA Fox Chase Canc Ctr, 7701 Burholme Ave, Philadelphia, PA 19111 USA Tennessee Oncol, Sarah Cannon Res Inst, Nashville, TN USA Amgen Inc, Thousand Oaks, CA USA Univ Complutense Madrid, Hosp Univ 12 Octubre, CNIO H12o Lung Canc Unit, Madrid, Spain Ciberonc, Madrid, Spain
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