Assessment of relative risk of second primary tumors after ovarian cancer and of the usefulness of double primary cases as a source of material for genetic studies with a cancer registry.

2.50
Hdl Handle:
http://hdl.handle.net/10541/99958
Title:
Assessment of relative risk of second primary tumors after ovarian cancer and of the usefulness of double primary cases as a source of material for genetic studies with a cancer registry.
Authors:
Shah, S; Evans, D Gareth R; Blair, Val; Burnell, L D; Birch, Jillian M
Abstract:
BACKGROUND: It now is accepted that a small proportion of people with certain forms of cancer have a dominantly inherited gene fault that predisposes them to it. This is more likely with an early age at onset or when the person has had multiple primary tumors. METHODS: Population-based data from the North West Regional Cancer Registry of England regarding 4157 ovarian cancer cases diagnosed between 1980 and 1989 were analyzed to determine the relative risks (RR) of second primary breast and colorectal carcinomas. RESULTS: Elevated risks approaching significance were observed for breast and colorectal carcinoma subsequent to ovarian cancer. After stratification into groups for ovarian histopathologic characteristics and age at onset, significantly elevated risks were obtained for both breast and colorectal tumors after ovarian carcinoma for women younger than 60 years of age at onset and with serous histopathologic characteristics (breast RR, 2.68, P < 0.05; colorectal RR, 4.25, P < 0.05). CONCLUSIONS: These results emphasize the need for greater awareness of the possibility of development of additional cancer after ovarian carcinoma in high-risk groups. Overall, the study supports the theory that breast, colorectal, and ovarian tumors are related genetically.
Affiliation:
Cancer Research Campaign (CRC) Paediatric and Familial Cancer Research Group, Christie Hospital, Manchester, United Kingdom.
Citation:
Assessment of relative risk of second primary tumors after ovarian cancer and of the usefulness of double primary cases as a source of material for genetic studies with a cancer registry. 1993, 72 (3):819-27 Cancer
Journal:
Cancer
Issue Date:
1-Aug-1993
URI:
http://hdl.handle.net/10541/99958
DOI:
10.1002/1097-0142(19930801)72:3<819::AID-CNCR2820720330>3.0.CO;2-U
PubMed ID:
8334636
Type:
Article
Language:
en
ISSN:
0008-543X
Appears in Collections:
All Christie Publications ; All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorShah, Sen
dc.contributor.authorEvans, D Gareth Ren
dc.contributor.authorBlair, Valen
dc.contributor.authorBurnell, L Den
dc.contributor.authorBirch, Jillian Men
dc.date.accessioned2010-05-28T11:46:46Z-
dc.date.available2010-05-28T11:46:46Z-
dc.date.issued1993-08-01-
dc.identifier.citationAssessment of relative risk of second primary tumors after ovarian cancer and of the usefulness of double primary cases as a source of material for genetic studies with a cancer registry. 1993, 72 (3):819-27 Canceren
dc.identifier.issn0008-543X-
dc.identifier.pmid8334636-
dc.identifier.doi10.1002/1097-0142(19930801)72:3<819::AID-CNCR2820720330>3.0.CO;2-U-
dc.identifier.urihttp://hdl.handle.net/10541/99958-
dc.description.abstractBACKGROUND: It now is accepted that a small proportion of people with certain forms of cancer have a dominantly inherited gene fault that predisposes them to it. This is more likely with an early age at onset or when the person has had multiple primary tumors. METHODS: Population-based data from the North West Regional Cancer Registry of England regarding 4157 ovarian cancer cases diagnosed between 1980 and 1989 were analyzed to determine the relative risks (RR) of second primary breast and colorectal carcinomas. RESULTS: Elevated risks approaching significance were observed for breast and colorectal carcinoma subsequent to ovarian cancer. After stratification into groups for ovarian histopathologic characteristics and age at onset, significantly elevated risks were obtained for both breast and colorectal tumors after ovarian carcinoma for women younger than 60 years of age at onset and with serous histopathologic characteristics (breast RR, 2.68, P < 0.05; colorectal RR, 4.25, P < 0.05). CONCLUSIONS: These results emphasize the need for greater awareness of the possibility of development of additional cancer after ovarian carcinoma in high-risk groups. Overall, the study supports the theory that breast, colorectal, and ovarian tumors are related genetically.en
dc.language.isoenen
dc.subjectBreast Canceren
dc.subjectColorectal Canceren
dc.subjectSecond Primary Canceren
dc.subjectOvarian Canceren
dc.subject.meshAdult-
dc.subject.meshAge Factors-
dc.subject.meshAged-
dc.subject.meshAged, 80 and over-
dc.subject.meshBreast Neoplasms-
dc.subject.meshColorectal Neoplasms-
dc.subject.meshEngland-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshIncidence-
dc.subject.meshMiddle Aged-
dc.subject.meshNeoplasms, Second Primary-
dc.subject.meshOvarian Neoplasms-
dc.subject.meshPedigree-
dc.subject.meshRegistries-
dc.subject.meshRisk Factors-
dc.titleAssessment of relative risk of second primary tumors after ovarian cancer and of the usefulness of double primary cases as a source of material for genetic studies with a cancer registry.en
dc.typeArticleen
dc.contributor.departmentCancer Research Campaign (CRC) Paediatric and Familial Cancer Research Group, Christie Hospital, Manchester, United Kingdom.en
dc.identifier.journalCanceren

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