The suitability of carboplatin solutions for 14-day continuous infusion by ambulatory pump: an HPLC-dynamic FAB study.

3.50
Hdl Handle:
http://hdl.handle.net/10541/99944
Title:
The suitability of carboplatin solutions for 14-day continuous infusion by ambulatory pump: an HPLC-dynamic FAB study.
Authors:
Hadfield, John A; McGown, Alan T; Dawson, Martin J; Thatcher, Nick; Fox, Brian W
Abstract:
The stability of aqueous carboplatin solutions over 14 days has been studied at 37 and 60 degrees C. High-performance liquid chromatography and dynamic FAB mass spectrometry studies have shown that carboplatin solutions were stable at 37 degrees C but degraded at 60 degrees C. Fluid loss through evaporation was significant at the higher temperature.
Affiliation:
CRC Department of Experimental Chemotherapy, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, UK.
Citation:
The suitability of carboplatin solutions for 14-day continuous infusion by ambulatory pump: an HPLC-dynamic FAB study. 1993, 11 (8):723-7 J Pharm Biomed Anal
Journal:
Journal of Pharmaceutical and Biomedical Analysis
Issue Date:
Aug-1993
URI:
http://hdl.handle.net/10541/99944
DOI:
10.1016/0731-7085(93)80181-Y
PubMed ID:
8257737
Type:
Article
Language:
en
ISSN:
0731-7085
Appears in Collections:
All Christie Publications ; All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorHadfield, John Aen
dc.contributor.authorMcGown, Alan Ten
dc.contributor.authorDawson, Martin Jen
dc.contributor.authorThatcher, Nicken
dc.contributor.authorFox, Brian Wen
dc.date.accessioned2010-05-27T15:08:54Z-
dc.date.available2010-05-27T15:08:54Z-
dc.date.issued1993-08-
dc.identifier.citationThe suitability of carboplatin solutions for 14-day continuous infusion by ambulatory pump: an HPLC-dynamic FAB study. 1993, 11 (8):723-7 J Pharm Biomed Analen
dc.identifier.issn0731-7085-
dc.identifier.pmid8257737-
dc.identifier.doi10.1016/0731-7085(93)80181-Y-
dc.identifier.urihttp://hdl.handle.net/10541/99944-
dc.description.abstractThe stability of aqueous carboplatin solutions over 14 days has been studied at 37 and 60 degrees C. High-performance liquid chromatography and dynamic FAB mass spectrometry studies have shown that carboplatin solutions were stable at 37 degrees C but degraded at 60 degrees C. Fluid loss through evaporation was significant at the higher temperature.en
dc.language.isoenen
dc.subject.meshCarboplatin-
dc.subject.meshChromatography, High Pressure Liquid-
dc.subject.meshDrug Stability-
dc.subject.meshInfusion Pumps-
dc.subject.meshInfusions, Intravenous-
dc.subject.meshSpectrometry, Mass, Fast Atom Bombardment-
dc.subject.meshTemperature-
dc.titleThe suitability of carboplatin solutions for 14-day continuous infusion by ambulatory pump: an HPLC-dynamic FAB study.en
dc.typeArticleen
dc.contributor.departmentCRC Department of Experimental Chemotherapy, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, UK.en
dc.identifier.journalJournal of Pharmaceutical and Biomedical Analysisen

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