Residual Ph- cells in chronic myeloid leukemia: detection and usefulness.
Affiliation
Department of Experimental Hematology, Paterson Institute for Cancer Research, Christie Hospital, Manchester, United Kingdom.Issue Date
1993-05
Metadata
Show full item recordAbstract
Bone marrow cells from patients with chronic myeloid leukemia (CML) in in vitro long-term bone marrow culture (LTBMC) show an impaired survival of Philadelphia (Ph) positive cells and, in a proportion of patients, the emergence of Philadelphia negative hemopoiesis. The standard conditions of in vitro cultures provide optimal purging effect. Selected patients can now have autologous bone marrow transplants (ABMT) with in vitro purged cells.Citation
Residual Ph- cells in chronic myeloid leukemia: detection and usefulness. 1993, 11 Suppl 1:59-61 Stem CellsJournal
Stem CellsDOI
10.1002/stem.5530110612PubMed ID
8318920Type
ArticleLanguage
enISSN
1066-5099ae974a485f413a2113503eed53cd6c53
10.1002/stem.5530110612
Scopus Count
Related articles
- [Autologous bone marrow transplantation for patients with chronic myelogenous leukemia after in vitro purging of the graft with bcr/abl antisense oligodeoxynucleotides].
- Authors: Sun J, Wu B, Liu Q, Feng R, Liu X, Meng F, Zhou S
- Issue date: 2000 Aug
- Autografting in Philadelphia (Ph)+ chronic myeloid leukaemia using cultured marrow: an update of a pilot study.
- Authors: Coutinho LH, Chang J, Brereton ML, Morgenstern GR, Scarffe JH, Harrison CJ, Yin JA, Darbyshire PJ, Burdach S, Dexter TM, Testa NG
- Issue date: 1997 May
- The effect of long-term marrow culture on the nonadherent Philadelphia chromosome-positive clone in chronic myelogenous leukemia: preliminary observations.
- Authors: O'Brien S, Kantarjian HM, Talpaz M, Cork A, Trujillo J, Beran M
- Issue date: 1987
- The detection of Philadelphia chromosome negative metaphases in long-term bone marrow cultures of the peripheral blood from patients with chronic myeloid leukemia predicts response to interferon-alpha 2a.
- Authors: Gronthos S, To LB, Moore S, Suttle JM, Juttner CA
- Issue date: 1992 Dec
- Detection of bcr-abl mRNA in single progenitor colonies from patients with chronic myeloid leukemia by PCR: comparison with cytogenetics and PCR from uncultured cells.
- Authors: Schulze E, Krahl R, Thalmeier K, Helbig W
- Issue date: 1995 Dec