Effect of irradiation treatment on gonadal function in men treated for germ cell cancer.

2.50
Hdl Handle:
http://hdl.handle.net/10541/99808
Title:
Effect of irradiation treatment on gonadal function in men treated for germ cell cancer.
Authors:
Shalet, Stephen M
Abstract:
Irradiation may have a profound effect on reproductive function. The schedule of the delivered irradiation (total dose, number of fractions and duration) is an important determinant of the radiobiological effect on the tissues involved and varies between different tissues and organs. Direct irradiation to the testis will, in lower doses, affect the germinal epithelium: doses of irradiation greater than 0.35 Gy cause aspermia which may be reversible. The time taken for recovery increases with larger doses, however, with doses in excess of 2 Gy aspermia may be permanent. At high radiation doses (> 20 Gy) Leydig cell function will also be affected.
Affiliation:
Department of Endocrinology, Christie Hospital NHS Trust, Manchester, UK.
Citation:
Effect of irradiation treatment on gonadal function in men treated for germ cell cancer. 1993, 23 (1):148-51; discussion 152 Eur. Urol.
Journal:
European Urology
Issue Date:
1993
URI:
http://hdl.handle.net/10541/99808
PubMed ID:
8386642
Type:
Article
Language:
en
ISSN:
0302-2838
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorShalet, Stephen Men
dc.date.accessioned2010-05-25T14:16:19Z-
dc.date.available2010-05-25T14:16:19Z-
dc.date.issued1993-
dc.identifier.citationEffect of irradiation treatment on gonadal function in men treated for germ cell cancer. 1993, 23 (1):148-51; discussion 152 Eur. Urol.en
dc.identifier.issn0302-2838-
dc.identifier.pmid8386642-
dc.identifier.urihttp://hdl.handle.net/10541/99808-
dc.description.abstractIrradiation may have a profound effect on reproductive function. The schedule of the delivered irradiation (total dose, number of fractions and duration) is an important determinant of the radiobiological effect on the tissues involved and varies between different tissues and organs. Direct irradiation to the testis will, in lower doses, affect the germinal epithelium: doses of irradiation greater than 0.35 Gy cause aspermia which may be reversible. The time taken for recovery increases with larger doses, however, with doses in excess of 2 Gy aspermia may be permanent. At high radiation doses (> 20 Gy) Leydig cell function will also be affected.en
dc.language.isoenen
dc.subjectGerm Cell and Embryonal Canceren
dc.subjectTeticular Canceren
dc.subject.meshAdult-
dc.subject.meshFertility-
dc.subject.meshHumans-
dc.subject.meshLeydig Cells-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshNeoplasms, Germ Cell and Embryonal-
dc.subject.meshRadiation Injuries-
dc.subject.meshSpermatogenesis-
dc.subject.meshTesticular Neoplasms-
dc.subject.meshTestis-
dc.titleEffect of irradiation treatment on gonadal function in men treated for germ cell cancer.en
dc.typeArticleen
dc.contributor.departmentDepartment of Endocrinology, Christie Hospital NHS Trust, Manchester, UK.en
dc.identifier.journalEuropean Urologyen

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