Structural abnormalities of the X chromosome in non-Hodgkin's lymphoma.

2.50
Hdl Handle:
http://hdl.handle.net/10541/99804
Title:
Structural abnormalities of the X chromosome in non-Hodgkin's lymphoma.
Authors:
Goyns, M H; Hammond, David W; Harrison, Christine J; Menasce, Lia P; Ross, F M; Hancock, Barry W
Abstract:
It has recently been reported that additional X chromosomes occur in over 30% of B-cell non-Hodgkin's lymphomas (NHL), and that monosomy of the X chromosome occurs in 38% of female patients with T-cell leukaemia or lymphoma. These observations have suggested a possible role for the X chromosome in the evolution of NHL. We have now examined 280 cases of NHL, and have identified 19 examples of structurally altered X chromosomes in the malignant cells from 17 of these cases. These abnormalities were mainly characterized by either a translocation involving Xp22, or a translocation/deletion involving Xq28. The relevance of these observations is discussed with respect to other published reports, and together they suggest that lymphoma-associated oncogenes may exist on the X chromosome at bands p22 or q28.
Affiliation:
Department of Clinical Oncology, Royal Hallamshire Hospital, Sheffield, UK.
Citation:
Structural abnormalities of the X chromosome in non-Hodgkin's lymphoma. 1993, 7 (6):848-52 Leukemia
Journal:
Leukemia
Issue Date:
Jun-1993
URI:
http://hdl.handle.net/10541/99804
PubMed ID:
8501979
Type:
Article
Language:
en
ISSN:
0887-6924
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorGoyns, M Hen
dc.contributor.authorHammond, David Wen
dc.contributor.authorHarrison, Christine Jen
dc.contributor.authorMenasce, Lia Pen
dc.contributor.authorRoss, F Men
dc.contributor.authorHancock, Barry Wen
dc.date.accessioned2010-05-25T11:58:38Z-
dc.date.available2010-05-25T11:58:38Z-
dc.date.issued1993-06-
dc.identifier.citationStructural abnormalities of the X chromosome in non-Hodgkin's lymphoma. 1993, 7 (6):848-52 Leukemiaen
dc.identifier.issn0887-6924-
dc.identifier.pmid8501979-
dc.identifier.urihttp://hdl.handle.net/10541/99804-
dc.description.abstractIt has recently been reported that additional X chromosomes occur in over 30% of B-cell non-Hodgkin's lymphomas (NHL), and that monosomy of the X chromosome occurs in 38% of female patients with T-cell leukaemia or lymphoma. These observations have suggested a possible role for the X chromosome in the evolution of NHL. We have now examined 280 cases of NHL, and have identified 19 examples of structurally altered X chromosomes in the malignant cells from 17 of these cases. These abnormalities were mainly characterized by either a translocation involving Xp22, or a translocation/deletion involving Xq28. The relevance of these observations is discussed with respect to other published reports, and together they suggest that lymphoma-associated oncogenes may exist on the X chromosome at bands p22 or q28.en
dc.language.isoenen
dc.subject.meshAneuploidy-
dc.subject.meshChromosome Aberrations-
dc.subject.meshChromosome Disorders-
dc.subject.meshChromosome Mapping-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshLymphoma, Non-Hodgkin-
dc.subject.meshMale-
dc.subject.meshX Chromosome-
dc.titleStructural abnormalities of the X chromosome in non-Hodgkin's lymphoma.en
dc.typeArticleen
dc.contributor.departmentDepartment of Clinical Oncology, Royal Hallamshire Hospital, Sheffield, UK.en
dc.identifier.journalLeukemiaen
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