The nature of atypical multinucleated stromal cells: a study of 37 cases from different sites.

2.50
Hdl Handle:
http://hdl.handle.net/10541/99797
Title:
The nature of atypical multinucleated stromal cells: a study of 37 cases from different sites.
Authors:
Pitt, M A; Roberts, I S; Agbamu, D A; Eyden, Brian P
Abstract:
The morphology, immunophenotype and ultrastructure of atypical multinucleated stromal cells in 37 specimens from different anatomical sites were compared. Overall, cellular morphology was similar between sites but nuclear features, immunophenotype and ultrastructure varied and reflected that of adjacent normal mononuclear stromal cells. It is concluded that the atypical multinucleated stromal cells represent a reactive change in the indigenous stromal cells. In all the cases mast cells were seen as a prominent component of the inflammatory infiltrate and many of them were intimately related to the atypical stromal cells. It is suggested that reactive stromal cell changes may relate to an interaction with mast cells.
Affiliation:
Department of Histopathology, Christie Hospital, Manchester, UK.
Citation:
The nature of atypical multinucleated stromal cells: a study of 37 cases from different sites. 1993, 23 (2):137-45 Histopathology
Journal:
Histopathology
Issue Date:
Aug-1993
URI:
http://hdl.handle.net/10541/99797
DOI:
10.1111/j.1365-2559.1993.tb00471.x
PubMed ID:
8406385
Type:
Article
Language:
en
ISSN:
0309-0167
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorPitt, M Aen
dc.contributor.authorRoberts, I Sen
dc.contributor.authorAgbamu, D Aen
dc.contributor.authorEyden, Brian Pen
dc.date.accessioned2010-05-25T11:00:29Z-
dc.date.available2010-05-25T11:00:29Z-
dc.date.issued1993-08-
dc.identifier.citationThe nature of atypical multinucleated stromal cells: a study of 37 cases from different sites. 1993, 23 (2):137-45 Histopathologyen
dc.identifier.issn0309-0167-
dc.identifier.pmid8406385-
dc.identifier.doi10.1111/j.1365-2559.1993.tb00471.x-
dc.identifier.urihttp://hdl.handle.net/10541/99797-
dc.description.abstractThe morphology, immunophenotype and ultrastructure of atypical multinucleated stromal cells in 37 specimens from different anatomical sites were compared. Overall, cellular morphology was similar between sites but nuclear features, immunophenotype and ultrastructure varied and reflected that of adjacent normal mononuclear stromal cells. It is concluded that the atypical multinucleated stromal cells represent a reactive change in the indigenous stromal cells. In all the cases mast cells were seen as a prominent component of the inflammatory infiltrate and many of them were intimately related to the atypical stromal cells. It is suggested that reactive stromal cell changes may relate to an interaction with mast cells.en
dc.language.isoenen
dc.subject.meshCell Nucleus-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshImmunoenzyme Techniques-
dc.subject.meshMale-
dc.subject.meshMicroscopy, Electron-
dc.subject.meshStromal Cells-
dc.titleThe nature of atypical multinucleated stromal cells: a study of 37 cases from different sites.en
dc.typeArticleen
dc.contributor.departmentDepartment of Histopathology, Christie Hospital, Manchester, UK.en
dc.identifier.journalHistopathologyen
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