2.50
Hdl Handle:
http://hdl.handle.net/10541/99793
Title:
Chondroid syringoma with hyaline cell change.
Authors:
Banerjee, Saumitra S; Harris, Martin; Eyden, Brian P; Howell, S; Wells, S; Mainwaring, A R
Abstract:
Four cases of chondroid syringoma containing large numbers of hyaline or plasmacytoid cells are described. Three cases occurred in the hand and one in the foot. Hyaline cells are commonly seen in mixed tumours and myoepitheliomas of salivary glands and rarely in chondroid syringomas. The hyaline-cell change in three of the cases initially caused diagnostic difficulties and the possibility of sarcoma was raised in two cases. In addition to the characteristic hyaline cells, the presence of tubulo-glandulo-ductal structures, benign squamous epithelium and myxochondroid stroma aided diagnosis. Immunohistochemically, the hyaline cells exhibited positivity for vimentin, cytokeratin, S-100 protein, carcino-embryonic antigen, focal glial fibrillary acidic protein (3 cases), neuron-specific enolase (3 cases) and focal alpha-smooth muscle actin (2 cases). Occasional cells were Ber EP4 positive (2 cases). In some cells, a striking peripheral ring-like positivity for cytokeratin and S-100 protein was noted. Ultrastructurally, desmosomes, varying numbers of tonofibrils and non-bundling intermediate filaments were seen. Scanty fine filaments with vague focal densities were detected in some cells. Our studies suggest that the hyaline cells represent modified epithelial as well as myoepithelial cells. One of our cases also exhibited collagenous spherulosis.
Affiliation:
Department of Histopathology, Christie Hospital NHS Trust, Manchester, UK.
Citation:
Chondroid syringoma with hyaline cell change. 1993, 22 (3):235-45 Histopathology
Journal:
Histopathology
Issue Date:
Mar-1993
URI:
http://hdl.handle.net/10541/99793
DOI:
10.1111/j.1365-2559.1993.tb00113.x
PubMed ID:
7684353
Type:
Article
Language:
en
ISSN:
0309-0167
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorBanerjee, Saumitra Sen
dc.contributor.authorHarris, Martinen
dc.contributor.authorEyden, Brian Pen
dc.contributor.authorHowell, Sen
dc.contributor.authorWells, Sen
dc.contributor.authorMainwaring, A Ren
dc.date.accessioned2010-05-25T10:38:15Z-
dc.date.available2010-05-25T10:38:15Z-
dc.date.issued1993-03-
dc.identifier.citationChondroid syringoma with hyaline cell change. 1993, 22 (3):235-45 Histopathologyen
dc.identifier.issn0309-0167-
dc.identifier.pmid7684353-
dc.identifier.doi10.1111/j.1365-2559.1993.tb00113.x-
dc.identifier.urihttp://hdl.handle.net/10541/99793-
dc.description.abstractFour cases of chondroid syringoma containing large numbers of hyaline or plasmacytoid cells are described. Three cases occurred in the hand and one in the foot. Hyaline cells are commonly seen in mixed tumours and myoepitheliomas of salivary glands and rarely in chondroid syringomas. The hyaline-cell change in three of the cases initially caused diagnostic difficulties and the possibility of sarcoma was raised in two cases. In addition to the characteristic hyaline cells, the presence of tubulo-glandulo-ductal structures, benign squamous epithelium and myxochondroid stroma aided diagnosis. Immunohistochemically, the hyaline cells exhibited positivity for vimentin, cytokeratin, S-100 protein, carcino-embryonic antigen, focal glial fibrillary acidic protein (3 cases), neuron-specific enolase (3 cases) and focal alpha-smooth muscle actin (2 cases). Occasional cells were Ber EP4 positive (2 cases). In some cells, a striking peripheral ring-like positivity for cytokeratin and S-100 protein was noted. Ultrastructurally, desmosomes, varying numbers of tonofibrils and non-bundling intermediate filaments were seen. Scanty fine filaments with vague focal densities were detected in some cells. Our studies suggest that the hyaline cells represent modified epithelial as well as myoepithelial cells. One of our cases also exhibited collagenous spherulosis.en
dc.language.isoenen
dc.subject.meshActins-
dc.subject.meshAdenoma, Sweat Gland-
dc.subject.meshAdult-
dc.subject.meshCarcinoembryonic Antigen-
dc.subject.meshCartilage-
dc.subject.meshCartilage Diseases-
dc.subject.meshFemale-
dc.subject.meshGlial Fibrillary Acidic Protein-
dc.subject.meshHumans-
dc.subject.meshImmunohistochemistry-
dc.subject.meshIntermediate Filaments-
dc.subject.meshKeratins-
dc.subject.meshMale-
dc.subject.meshMicroscopy, Electron-
dc.subject.meshMiddle Aged-
dc.subject.meshPhosphopyruvate Hydratase-
dc.subject.meshS100 Proteins-
dc.subject.meshVimentin-
dc.titleChondroid syringoma with hyaline cell change.en
dc.typeArticleen
dc.contributor.departmentDepartment of Histopathology, Christie Hospital NHS Trust, Manchester, UK.en
dc.identifier.journalHistopathologyen

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