Bone marrow transplantation for acute myeloblastic leukaemia: an EBMT Leukaemia Working Party prospective analysis from HLA-typing.

2.50
Hdl Handle:
http://hdl.handle.net/10541/99780
Title:
Bone marrow transplantation for acute myeloblastic leukaemia: an EBMT Leukaemia Working Party prospective analysis from HLA-typing.
Authors:
Ljungman, P; De Witte, T; Verdonck, L; Gahrton, G; Freycon, F; Gravett, P; McCann, S; Morgenstern, Godfrey R; Nikoskelainen, J; Powles, R
Abstract:
The optimal post-remission therapy for patients with acute myeloblastic leukaemia remains controversial. Allogeneic bone marrow transplantation, autologous bone marrow transplantation, and consolidation chemotherapy are the major options. In order to evaluate their respective value the European Group for Bone Marrow Transplantation conducted a prospective registration study. Patients with newly diagnosed acute myeloblastic leukaemia were registered at the time of HLA-typing and intention to treat in case of presence or absence of an HLA-identical donor was recorded. 27/79 (34%) patients HLA-typed at diagnosis had an identical donor identified. The estimated survivals at 3 years from HLA-typing were 44% and 21% among patients with or without HLA-identical donor, respectively (P = 0.02). 22/26 (85%) patients for whom allogeneic bone marrow transplantation was intended were transplanted but only 15/47 (32%) patients for whom autologous bone marrow transplantation was intended were indeed transplanted (P < 0.001). The survival was 50%, 29% and 17% (P = 0.004) for patients treated with allogeneic bone marrow transplantation, autologous bone marrow transplantation, or chemotherapy, respectively. 40/68 patients HLA-typed in first complete remission had an HLA-identical donor. The estimated 3-year survival among patients typed in first remission with and without HLA-identical donors was 42% and 35% (n.s.), respectively. This technique of early patient registration illustrates the problems of patient selection during the course of the disease and might be used as a complement to randomized trials when comparing bone marrow transplantation and other treatment options.
Affiliation:
Department of Medicine, Huddinge University Hospital, Sweden.
Citation:
Bone marrow transplantation for acute myeloblastic leukaemia: an EBMT Leukaemia Working Party prospective analysis from HLA-typing. 1993, 84 (1):61-6 Br. J. Haematol.
Journal:
British Journal of Haematology
Issue Date:
May-1993
URI:
http://hdl.handle.net/10541/99780
DOI:
10.1111/j.1365-2141.1993.tb03025.x
PubMed ID:
8338779
Type:
Article
Language:
en
ISSN:
0007-1048
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorLjungman, Pen
dc.contributor.authorDe Witte, Ten
dc.contributor.authorVerdonck, Len
dc.contributor.authorGahrton, Gen
dc.contributor.authorFreycon, Fen
dc.contributor.authorGravett, Pen
dc.contributor.authorMcCann, Sen
dc.contributor.authorMorgenstern, Godfrey Ren
dc.contributor.authorNikoskelainen, Jen
dc.contributor.authorPowles, Ren
dc.date.accessioned2010-05-25T12:02:21Z-
dc.date.available2010-05-25T12:02:21Z-
dc.date.issued1993-05-
dc.identifier.citationBone marrow transplantation for acute myeloblastic leukaemia: an EBMT Leukaemia Working Party prospective analysis from HLA-typing. 1993, 84 (1):61-6 Br. J. Haematol.en
dc.identifier.issn0007-1048-
dc.identifier.pmid8338779-
dc.identifier.doi10.1111/j.1365-2141.1993.tb03025.x-
dc.identifier.urihttp://hdl.handle.net/10541/99780-
dc.description.abstractThe optimal post-remission therapy for patients with acute myeloblastic leukaemia remains controversial. Allogeneic bone marrow transplantation, autologous bone marrow transplantation, and consolidation chemotherapy are the major options. In order to evaluate their respective value the European Group for Bone Marrow Transplantation conducted a prospective registration study. Patients with newly diagnosed acute myeloblastic leukaemia were registered at the time of HLA-typing and intention to treat in case of presence or absence of an HLA-identical donor was recorded. 27/79 (34%) patients HLA-typed at diagnosis had an identical donor identified. The estimated survivals at 3 years from HLA-typing were 44% and 21% among patients with or without HLA-identical donor, respectively (P = 0.02). 22/26 (85%) patients for whom allogeneic bone marrow transplantation was intended were transplanted but only 15/47 (32%) patients for whom autologous bone marrow transplantation was intended were indeed transplanted (P < 0.001). The survival was 50%, 29% and 17% (P = 0.004) for patients treated with allogeneic bone marrow transplantation, autologous bone marrow transplantation, or chemotherapy, respectively. 40/68 patients HLA-typed in first complete remission had an HLA-identical donor. The estimated 3-year survival among patients typed in first remission with and without HLA-identical donors was 42% and 35% (n.s.), respectively. This technique of early patient registration illustrates the problems of patient selection during the course of the disease and might be used as a complement to randomized trials when comparing bone marrow transplantation and other treatment options.en
dc.language.isoenen
dc.subjectAcute Myeloid Leukaemiaen
dc.subject.meshAdolescent-
dc.subject.meshAdult-
dc.subject.meshBone Marrow Transplantation-
dc.subject.meshHLA Antigens-
dc.subject.meshHistocompatibility Testing-
dc.subject.meshHumans-
dc.subject.meshLeukemia, Myeloid, Acute-
dc.subject.meshMiddle Aged-
dc.subject.meshProspective Studies-
dc.subject.meshTransplantation, Autologous-
dc.subject.meshTransplantation, Homologous-
dc.subject.meshTreatment Outcome-
dc.titleBone marrow transplantation for acute myeloblastic leukaemia: an EBMT Leukaemia Working Party prospective analysis from HLA-typing.en
dc.typeArticleen
dc.contributor.departmentDepartment of Medicine, Huddinge University Hospital, Sweden.en
dc.identifier.journalBritish Journal of Haematologyen

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