Leiomyosarcoma versus myofibrosarcoma: observations and terminology.

2.50
Hdl Handle:
http://hdl.handle.net/10541/99769
Title:
Leiomyosarcoma versus myofibrosarcoma: observations and terminology.
Authors:
Eyden, Brian P; Christensen, L
Abstract:
Two spindle cell sarcomas, which showed similarities in light microscopic histology and immunostaining and were diagnosed as leiomyosarcomas by these criteria, were compared ultrastructurally to show the value of electron microscopy in subtyping these neoplasms. Both were subcutaneous, case 1 occurring in the nasolabial fold and case 2 in the upper calf. Both consisted of fascicles of spindle cells, and both stained positively for vimentin and alpha-smooth muscle actin; only case 2 stained additionally for desmin. Case 1 showed strong and case 2 weak or negative staining for fibronectin. By electron microscopy, case 1 contained prominent rough endoplasmic reticulum, peripheral fine filaments with focal densities, and fibronexus junctions. By contrast, case 2 was characterized by an external lamina and well-developed bundles of fine filaments with focal densities. Case 2 was considered a typical leiomyosarcoma, and case 1 was interpreted as showing myofibroblastic differentiation. The nomenclature for these myofibroblastic tumors is discussed, and myofibrosarcoma and leiomyosarcoma, myofibroblastic variant are suggested as suitable terms.
Affiliation:
Department of Histopathology, Christie Hospital National Health Service Trust, Manchester, United Kingdom.
Citation:
Leiomyosarcoma versus myofibrosarcoma: observations and terminology., 17 (3-4):231-9 Ultrastruct Pathol
Journal:
Ultrastructural Pathology
Issue Date:
1993
URI:
http://hdl.handle.net/10541/99769
DOI:
10.3109/01913129309027769
PubMed ID:
8266588
Type:
Article
Language:
en
ISSN:
0191-3123
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorEyden, Brian Pen
dc.contributor.authorChristensen, Len
dc.date.accessioned2010-05-24T16:02:33Z-
dc.date.available2010-05-24T16:02:33Z-
dc.date.issued1993-
dc.identifier.citationLeiomyosarcoma versus myofibrosarcoma: observations and terminology., 17 (3-4):231-9 Ultrastruct Patholen
dc.identifier.issn0191-3123-
dc.identifier.pmid8266588-
dc.identifier.doi10.3109/01913129309027769-
dc.identifier.urihttp://hdl.handle.net/10541/99769-
dc.description.abstractTwo spindle cell sarcomas, which showed similarities in light microscopic histology and immunostaining and were diagnosed as leiomyosarcomas by these criteria, were compared ultrastructurally to show the value of electron microscopy in subtyping these neoplasms. Both were subcutaneous, case 1 occurring in the nasolabial fold and case 2 in the upper calf. Both consisted of fascicles of spindle cells, and both stained positively for vimentin and alpha-smooth muscle actin; only case 2 stained additionally for desmin. Case 1 showed strong and case 2 weak or negative staining for fibronectin. By electron microscopy, case 1 contained prominent rough endoplasmic reticulum, peripheral fine filaments with focal densities, and fibronexus junctions. By contrast, case 2 was characterized by an external lamina and well-developed bundles of fine filaments with focal densities. Case 2 was considered a typical leiomyosarcoma, and case 1 was interpreted as showing myofibroblastic differentiation. The nomenclature for these myofibroblastic tumors is discussed, and myofibrosarcoma and leiomyosarcoma, myofibroblastic variant are suggested as suitable terms.en
dc.language.isoenen
dc.subjectFacial Canceren
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshFacial Neoplasms-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshImmunohistochemistry-
dc.subject.meshLeg-
dc.subject.meshLeiomyosarcoma-
dc.subject.meshMicroscopy, Electron-
dc.subject.meshMyosarcoma-
dc.subject.meshPhenotype-
dc.subject.meshTerminology as Topic-
dc.titleLeiomyosarcoma versus myofibrosarcoma: observations and terminology.en
dc.typeArticleen
dc.contributor.departmentDepartment of Histopathology, Christie Hospital National Health Service Trust, Manchester, United Kingdom.en
dc.identifier.journalUltrastructural Pathologyen

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