Inverse relationship between hyaluronan and collagens in development and angiogenesis.

2.50
Hdl Handle:
http://hdl.handle.net/10541/99767
Title:
Inverse relationship between hyaluronan and collagens in development and angiogenesis.
Authors:
Rooney, P; Kumar, Shant
Abstract:
The extracellular matrix plays a vital role in regulating normal tissue development and function--largely via the specific arrangement of macromolecules such as collagens, proteoglycans, glycosaminoglycans and glycoproteins. Previous reports have concentrated on associations between combinations of collagens/proteoglycans, collagens/glycoproteins and proteoglycans/glycosaminoglycans whilst little information is available on associations between collagens and free glycosaminoglycans. In this review, we discuss possible associations between collagens and the glycosaminoglycan hyaluronan; macromolecules which are known to exhibit changes in amount and composition during development and under pathological conditions. We demonstrate two types of collagen/hyaluronan association in vivo: the first, during the formation of extracellular matrix structures where neither collagens nor hyaluronan are degraded, resulting in the regulation of collagen fibrillogenesis, and the second, involving an inverse correlation between collagen synthesis and hyaluronan degradation and vice versa. We suggest that associations between collagens and hyaluronan play an important role in the initiation and maintenance of angiogenesis and put forward a model of cartilage vascularisation which relies on these associations.
Affiliation:
Department of Pathological Sciences, University of Manchester, UK.
Citation:
Inverse relationship between hyaluronan and collagens in development and angiogenesis. 1993, 54 (1):1-9 Differentiation
Journal:
Differentiation
Issue Date:
Aug-1993
URI:
http://hdl.handle.net/10541/99767
DOI:
10.1111/j.1432-0436.1993.tb00653.x
PubMed ID:
7691668
Type:
Article
Language:
en
ISSN:
0301-4681
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorRooney, Pen
dc.contributor.authorKumar, Shanten
dc.date.accessioned2010-05-24T15:48:12Z-
dc.date.available2010-05-24T15:48:12Z-
dc.date.issued1993-08-
dc.identifier.citationInverse relationship between hyaluronan and collagens in development and angiogenesis. 1993, 54 (1):1-9 Differentiationen
dc.identifier.issn0301-4681-
dc.identifier.pmid7691668-
dc.identifier.doi10.1111/j.1432-0436.1993.tb00653.x-
dc.identifier.urihttp://hdl.handle.net/10541/99767-
dc.description.abstractThe extracellular matrix plays a vital role in regulating normal tissue development and function--largely via the specific arrangement of macromolecules such as collagens, proteoglycans, glycosaminoglycans and glycoproteins. Previous reports have concentrated on associations between combinations of collagens/proteoglycans, collagens/glycoproteins and proteoglycans/glycosaminoglycans whilst little information is available on associations between collagens and free glycosaminoglycans. In this review, we discuss possible associations between collagens and the glycosaminoglycan hyaluronan; macromolecules which are known to exhibit changes in amount and composition during development and under pathological conditions. We demonstrate two types of collagen/hyaluronan association in vivo: the first, during the formation of extracellular matrix structures where neither collagens nor hyaluronan are degraded, resulting in the regulation of collagen fibrillogenesis, and the second, involving an inverse correlation between collagen synthesis and hyaluronan degradation and vice versa. We suggest that associations between collagens and hyaluronan play an important role in the initiation and maintenance of angiogenesis and put forward a model of cartilage vascularisation which relies on these associations.en
dc.language.isoenen
dc.subject.meshAnimals-
dc.subject.meshCartilage-
dc.subject.meshCells, Cultured-
dc.subject.meshCollagen-
dc.subject.meshConnective Tissue-
dc.subject.meshExtracellular Matrix-
dc.subject.meshHyaluronic Acid-
dc.subject.meshNeovascularization, Pathologic-
dc.titleInverse relationship between hyaluronan and collagens in development and angiogenesis.en
dc.typeArticleen
dc.contributor.departmentDepartment of Pathological Sciences, University of Manchester, UK.en
dc.identifier.journalDifferentiationen
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