Immunophenotype and ultrastructure of alveolar soft part sarcoma.

2.50
Hdl Handle:
http://hdl.handle.net/10541/99765
Title:
Immunophenotype and ultrastructure of alveolar soft part sarcoma.
Authors:
Menasce, Lia P; Eyden, Brian P; Edmondson, David; Harris, Martin
Abstract:
Nine cases of alveolar soft part sarcoma were studied in terms of their immunoreactivity towards intermediate filaments and muscle markers, and their ultrastructure with regard to muscle features and the cytoplasmic crystals characteristic of this tumour. Inconsistent expression of alpha-smooth muscle actin, vimentin and desmin were found. No unambiguous muscle cell characteristics were identified by electron microscopy, although multiple subplasmalemmal densities with overlying lamina were emphasised as a typical but not specific muscle feature. Classical alveolar soft part sarcoma crystals at the ultrastructural level were absent throughout, but pseudo-crystals with a pre-crystalline finely filamentous content were numerous in one case. The results were integrated into a comprehensive comparison with the literature. It is clear that immunohistochemical evidence of striated muscle differentiation is detectable in some but not all cases of ASPS. The detection of Myo D1 protein in the small numbers of ASPSs so far studied for this gene product raises the possibility that in the majority of ASPSs this is the only evidence of early striated muscle differentiation and that only in the minority is it able to induce desmin production. Study of a substantial series for Myo D1 is required to explore this possibility.
Affiliation:
Department of Histopathology, Christie Hospital National Health Service Trust, Manchester, U.K.
Citation:
Immunophenotype and ultrastructure of alveolar soft part sarcoma. 1993, 25 (3):377-87 J. Submicrosc. Cytol. Pathol.
Journal:
Journal of Submicroscopic Cytology and Pathology
Issue Date:
Jul-1993
URI:
http://hdl.handle.net/10541/99765
PubMed ID:
8402538
Type:
Article
Language:
en
ISSN:
1122-9497
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorMenasce, Lia Pen
dc.contributor.authorEyden, Brian Pen
dc.contributor.authorEdmondson, Daviden
dc.contributor.authorHarris, Martinen
dc.date.accessioned2010-05-24T15:46:01Z-
dc.date.available2010-05-24T15:46:01Z-
dc.date.issued1993-07-
dc.identifier.citationImmunophenotype and ultrastructure of alveolar soft part sarcoma. 1993, 25 (3):377-87 J. Submicrosc. Cytol. Pathol.en
dc.identifier.issn1122-9497-
dc.identifier.pmid8402538-
dc.identifier.urihttp://hdl.handle.net/10541/99765-
dc.description.abstractNine cases of alveolar soft part sarcoma were studied in terms of their immunoreactivity towards intermediate filaments and muscle markers, and their ultrastructure with regard to muscle features and the cytoplasmic crystals characteristic of this tumour. Inconsistent expression of alpha-smooth muscle actin, vimentin and desmin were found. No unambiguous muscle cell characteristics were identified by electron microscopy, although multiple subplasmalemmal densities with overlying lamina were emphasised as a typical but not specific muscle feature. Classical alveolar soft part sarcoma crystals at the ultrastructural level were absent throughout, but pseudo-crystals with a pre-crystalline finely filamentous content were numerous in one case. The results were integrated into a comprehensive comparison with the literature. It is clear that immunohistochemical evidence of striated muscle differentiation is detectable in some but not all cases of ASPS. The detection of Myo D1 protein in the small numbers of ASPSs so far studied for this gene product raises the possibility that in the majority of ASPSs this is the only evidence of early striated muscle differentiation and that only in the minority is it able to induce desmin production. Study of a substantial series for Myo D1 is required to explore this possibility.en
dc.language.isoenen
dc.subjectSoft Tissue Canceren
dc.subject.meshActins-
dc.subject.meshAdolescent-
dc.subject.meshAdult-
dc.subject.meshChild-
dc.subject.meshCrystallization-
dc.subject.meshDesmin-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshImmunohistochemistry-
dc.subject.meshImmunophenotyping-
dc.subject.meshIntermediate Filament Proteins-
dc.subject.meshMale-
dc.subject.meshMicroscopy, Electron-
dc.subject.meshMyoD Protein-
dc.subject.meshSarcoma-
dc.subject.meshSoft Tissue Neoplasms-
dc.subject.meshVimentin-
dc.titleImmunophenotype and ultrastructure of alveolar soft part sarcoma.en
dc.typeArticleen
dc.contributor.departmentDepartment of Histopathology, Christie Hospital National Health Service Trust, Manchester, U.K.en
dc.identifier.journalJournal of Submicroscopic Cytology and Pathologyen

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