Adrenocorticotrophin and cortisol secretion in children after low dose cranial irradiation.

2.50
Hdl Handle:
http://hdl.handle.net/10541/99747
Title:
Adrenocorticotrophin and cortisol secretion in children after low dose cranial irradiation.
Authors:
Crowne, Elizabeth C; Wallace, W Hamish B; Gibson, S; Moore, C M; White, A; Shalet, Stephen M
Abstract:
OBJECTIVE: We investigated the effect of low dose cranial irradiation (18-24 Gy) on spontaneous ACTH and cortisol secretion in children. DESIGN: We analysed 24-hour plasma ACTH and cortisol profiles sampled at 20-minute intervals. PATIENTS: Twenty long-term survivors of acute lymphoblastic leukaemia were studied and results compared with those in 14 normal children. MEASUREMENTS: ACTH and cortisol profiles were analysed by Fourier transformation and spectral analysis of stationarized data, autocorrelation and coherency analysis. RESULTS: The normal circadian rhythms of ACTH and cortisol were preserved in the children after cranial irradiation. The median 0900 h and midnight values were 1.50(0.8-6.4)pmol/l and 1.0(0.6-3.7)pmol/l respectively for ACTH and 282(48-1913)nmol/l and 57.5(44-637)nmol/l respectively for cortisol, and were not significantly different from those in the normal group. Fourier transformation revealed dominant periodicities for ACTH at 0.7-1.1 h, equivalent to 22-34 ACTH secretory bursts per 24 hours, and for cortisol at 0.7-1.1 h and 2-4.8 h. Similar results were found in the normal group. Coherency analysis indicated a significant shared periodicity of 0.7-1.2 h in nine children, corresponding to 20-34 related secretory bursts in 24 hours for ACTH and cortisol. After pooling the coherency spectra in the cranially irradiated group, comparison with the pooled data from the normal group revealed no significant difference between the two groups in the relationship between the two hormones. CONCLUSION: No significant disruption of spontaneous ACTH or cortisol secretion, either in the amount or pattern of hormones secreted, was found in children after low dose cranial irradiation (18-24 Gy).
Affiliation:
Department of Endocrinology, Christie Hospital, Manchester, UK.
Citation:
Adrenocorticotrophin and cortisol secretion in children after low dose cranial irradiation. 1993, 39 (3):297-305 Clin. Endocrinol. (Oxf)
Journal:
Clinical Endocrinology
Issue Date:
Sep-1993
URI:
http://hdl.handle.net/10541/99747
DOI:
10.1111/j.1365-2265.1993.tb02369.x
PubMed ID:
8222292
Type:
Article
Language:
en
ISSN:
0300-0664
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorCrowne, Elizabeth Cen
dc.contributor.authorWallace, W Hamish Ben
dc.contributor.authorGibson, Sen
dc.contributor.authorMoore, C Men
dc.contributor.authorWhite, Aen
dc.contributor.authorShalet, Stephen Men
dc.date.accessioned2010-05-24T16:23:11Z-
dc.date.available2010-05-24T16:23:11Z-
dc.date.issued1993-09-
dc.identifier.citationAdrenocorticotrophin and cortisol secretion in children after low dose cranial irradiation. 1993, 39 (3):297-305 Clin. Endocrinol. (Oxf)en
dc.identifier.issn0300-0664-
dc.identifier.pmid8222292-
dc.identifier.doi10.1111/j.1365-2265.1993.tb02369.x-
dc.identifier.urihttp://hdl.handle.net/10541/99747-
dc.description.abstractOBJECTIVE: We investigated the effect of low dose cranial irradiation (18-24 Gy) on spontaneous ACTH and cortisol secretion in children. DESIGN: We analysed 24-hour plasma ACTH and cortisol profiles sampled at 20-minute intervals. PATIENTS: Twenty long-term survivors of acute lymphoblastic leukaemia were studied and results compared with those in 14 normal children. MEASUREMENTS: ACTH and cortisol profiles were analysed by Fourier transformation and spectral analysis of stationarized data, autocorrelation and coherency analysis. RESULTS: The normal circadian rhythms of ACTH and cortisol were preserved in the children after cranial irradiation. The median 0900 h and midnight values were 1.50(0.8-6.4)pmol/l and 1.0(0.6-3.7)pmol/l respectively for ACTH and 282(48-1913)nmol/l and 57.5(44-637)nmol/l respectively for cortisol, and were not significantly different from those in the normal group. Fourier transformation revealed dominant periodicities for ACTH at 0.7-1.1 h, equivalent to 22-34 ACTH secretory bursts per 24 hours, and for cortisol at 0.7-1.1 h and 2-4.8 h. Similar results were found in the normal group. Coherency analysis indicated a significant shared periodicity of 0.7-1.2 h in nine children, corresponding to 20-34 related secretory bursts in 24 hours for ACTH and cortisol. After pooling the coherency spectra in the cranially irradiated group, comparison with the pooled data from the normal group revealed no significant difference between the two groups in the relationship between the two hormones. CONCLUSION: No significant disruption of spontaneous ACTH or cortisol secretion, either in the amount or pattern of hormones secreted, was found in children after low dose cranial irradiation (18-24 Gy).en
dc.language.isoenen
dc.subjectPrecursor Cell Lymphoblastic Leukaemia-Lymphomaen
dc.subject.meshAdolescent-
dc.subject.meshAdrenocorticotropic Hormone-
dc.subject.meshChild-
dc.subject.meshCranial Irradiation-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshHydrocortisone-
dc.subject.meshMale-
dc.subject.meshPrecursor Cell Lymphoblastic Leukemia-Lymphoma-
dc.subject.meshRadiotherapy Dosage-
dc.subject.meshSecretory Rate-
dc.titleAdrenocorticotrophin and cortisol secretion in children after low dose cranial irradiation.en
dc.typeArticleen
dc.contributor.departmentDepartment of Endocrinology, Christie Hospital, Manchester, UK.en
dc.identifier.journalClinical Endocrinologyen

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