Increased frequency of HLA-DPB1*0301 in Hodgkin's disease suggests that susceptibility is HVR-sequence and subtype-associated.
Authors
Taylor, G MGokhale, D A
Crowther, Derek
Woll, Penella J
Harris, Martin
Alexander, F
Jarrett, R
Cartwright, R A
Affiliation
Immunogenetics Laboratory, St. Mary's Hospital, Manchester, UK.Issue Date
1996-05
Metadata
Show full item recordAbstract
Hodgkin's disease (HD) is a complex lymphoma-like disease which occurs as four main subtypes, nodular sclerosing (NS), mixed cellularity (MC), lymphocyte predominant (LP) and lymphocyte depleted (LD). Suggestions from epidemiological studies that HD may represent an unusual response to infection imply that the lack of previous response could be due to genetic factors. Following recent reports suggesting that there is an increased frequency of HLA-DPB1*0301 in Hodgkins disease, we have studied DPB1 in two series of patients using molecular typing methods. One series is a retrospective group of 118 patients over the age of 15 years from a single centre, and the other is a multi-centre prospective group of 45 patients between the age of 16 and 24 years. In both series, the percentage of HD patients with DPB1*0301 is greater than in the controls, confirming that this seems to be an HD-susceptibility allele. However, extension of the analysis in relation to HD subtype shows that the increase in *0301 is present in nodular sclerosing (NS), mixed cellularity (MC) and lymphocyte predominant patients (LP) HD patients, but preliminary evidence suggests an increase in *0401, and possibly *0501 in MC- and LP-HD. The DPB1 hypervariable region (HVR) amino-acid motif Asp55, Glu56 (*0301-like, HVR-C) is increased in NS compared with non-NS (ie MC+LP), whereas the frequency of Ala55, Ala56 (*0401-like) is increased in non-NS compared with NS. Conversely, Asp84, Glu85Ala86(*0301-like, HVR-F) motif is more frequent in NS than non-NS patients, but there is no increase in Gly84, Gly855, Pro86 (*0401-like). These findings suggest that genetic susceptibility in HD may reside at the level of HVR-encoded DPB1 peptide-binding residues, rather than with a specific allele, and that this may in some way influence the HD subtype.Citation
Increased frequency of HLA-DPB1*0301 in Hodgkin's disease suggests that susceptibility is HVR-sequence and subtype-associated. 1996, 10 (5):854-9 LeukemiaJournal
LeukemiaPubMed ID
8656683Type
ArticleLanguage
enISSN
0887-6924Related articles
- Further investigation of the role of HLA-DPB1 in adult Hodgkin's disease (HD) suggests an influence on susceptibility to different HD subtypes.
- Authors: Taylor GM, Gokhale DA, Crowther D, Woll PJ, Harris M, Ryder D, Ayres M, Radford JA
- Issue date: 1999 Jul
- Increased frequency of HLA-DPB1*0301 in Hodgkin's disease suggests that susceptibility is HVR-sequence and subtype associated: response to Dorak, Mills, Poynton and Burnett.
- Authors: Taylor GM, Gokhale DA
- Issue date: 1996 Nov
- Molecular genetic analysis of a family with a history of Hodgkin's disease and dyschondrosteosis.
- Authors: Gokhale DA, Evans DG, Crowther D, Woll P, Watson CJ, Dearden SP, Fergusson WD, Stevens RF, Taylor GM
- Issue date: 1995 May
- HLA-DQB1 and -DPB1 allele profile in HIV infected patients with and without pulmonary tuberculosis of south India.
- Authors: Selvaraj P, Raghavan S, Swaminathan S, Alagarasu K, Narendran G, Narayanan PR
- Issue date: 2008 Sep
- A clinical and epidemiological study of human leukocyte antigen-DPB alleles in Hodgkin's disease.
- Authors: Oza AM, Tonks S, Lim J, Fleetwood MA, Lister TA, Bodmer JG
- Issue date: 1994 Oct 1