The effect on diagnostic quality of using dual isotope imaging for 81Krm ventilation and 99Tcm-MAA perfusion lung scanning.

2.50
Hdl Handle:
http://hdl.handle.net/10541/99318
Title:
The effect on diagnostic quality of using dual isotope imaging for 81Krm ventilation and 99Tcm-MAA perfusion lung scanning.
Authors:
Hastings, David L; Jeans, Steve; Wall, W H; Hall, B J; Miller, D E
Abstract:
It is the practice in some centres to use dual isotope imaging to reduce imaging times in lung ventilation and perfusion studies with 81Krm gas and 99Tcm-macroaggregated albumin (99Tcm-MAA) by simultaneous acquisition of the two images. The resulting loss of image caused by cross-talk between the two energy windows was investigated using two phantoms, one with cold 99Tcm lesions of varying size and contrast, and the other a uniform field of 81Krm. It was found that, under scatter conditions typical of a patient study, the use of dual isotope acquisition and a krypton generator of 470 MBq or greater resulted in a perceptible loss of image quality with lesions up to 4 cm in diameter being missed. On an older camera system, without modern energy and linearity correction facilities, a lower generator activity of only 120 MBq was sufficient to cause image degradation even under very low scatter conditions. Seventy-five patient studies were performed using both single and dual isotope imaging with generator activities ranging from 80 to 282 MBq. At these low generator activities, the studies did not demonstrate any differences between the images that would result in a different diagnosis. We conclude that the use of dual isotope V/Q scanning reduces the diagnostic value of the perfusion image if the activity of the 81Krm generator is too high, although at generator activities of 300 MBq or less no loss of image quality will occur on modern camera systems.
Affiliation:
North Western Medical Physics Department, Christie Hospital NHS Trust, Withington, Manchester, UK.
Citation:
The effect on diagnostic quality of using dual isotope imaging for 81Krm ventilation and 99Tcm-MAA perfusion lung scanning. 1995, 16 (4):281-9 Nucl Med Commun
Journal:
Nuclear Medicine Communications
Issue Date:
Apr-1995
URI:
http://hdl.handle.net/10541/99318
PubMed ID:
7624109
Type:
Article
Language:
en
ISSN:
0143-3636
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorHastings, David Len
dc.contributor.authorJeans, Steveen
dc.contributor.authorWall, W Hen
dc.contributor.authorHall, B Jen
dc.contributor.authorMiller, D Een
dc.date.accessioned2010-05-19T13:19:36Z-
dc.date.available2010-05-19T13:19:36Z-
dc.date.issued1995-04-
dc.identifier.citationThe effect on diagnostic quality of using dual isotope imaging for 81Krm ventilation and 99Tcm-MAA perfusion lung scanning. 1995, 16 (4):281-9 Nucl Med Communen
dc.identifier.issn0143-3636-
dc.identifier.pmid7624109-
dc.identifier.urihttp://hdl.handle.net/10541/99318-
dc.description.abstractIt is the practice in some centres to use dual isotope imaging to reduce imaging times in lung ventilation and perfusion studies with 81Krm gas and 99Tcm-macroaggregated albumin (99Tcm-MAA) by simultaneous acquisition of the two images. The resulting loss of image caused by cross-talk between the two energy windows was investigated using two phantoms, one with cold 99Tcm lesions of varying size and contrast, and the other a uniform field of 81Krm. It was found that, under scatter conditions typical of a patient study, the use of dual isotope acquisition and a krypton generator of 470 MBq or greater resulted in a perceptible loss of image quality with lesions up to 4 cm in diameter being missed. On an older camera system, without modern energy and linearity correction facilities, a lower generator activity of only 120 MBq was sufficient to cause image degradation even under very low scatter conditions. Seventy-five patient studies were performed using both single and dual isotope imaging with generator activities ranging from 80 to 282 MBq. At these low generator activities, the studies did not demonstrate any differences between the images that would result in a different diagnosis. We conclude that the use of dual isotope V/Q scanning reduces the diagnostic value of the perfusion image if the activity of the 81Krm generator is too high, although at generator activities of 300 MBq or less no loss of image quality will occur on modern camera systems.en
dc.language.isoenen
dc.subject.meshHumans-
dc.subject.meshKrypton Radioisotopes-
dc.subject.meshLung-
dc.subject.meshLung Diseases-
dc.subject.meshModels, Structural-
dc.subject.meshPulmonary Embolism-
dc.subject.meshScattering, Radiation-
dc.subject.meshTechnetium Tc 99m Aggregated Albumin-
dc.subject.meshVentilation-Perfusion Ratio-
dc.titleThe effect on diagnostic quality of using dual isotope imaging for 81Krm ventilation and 99Tcm-MAA perfusion lung scanning.en
dc.typeArticleen
dc.contributor.departmentNorth Western Medical Physics Department, Christie Hospital NHS Trust, Withington, Manchester, UK.en
dc.identifier.journalNuclear Medicine Communicationsen

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