Apoptosis, intrinsic radiosensitivity and prediction of radiotherapy response in cervical carcinoma.

2.50
Hdl Handle:
http://hdl.handle.net/10541/99306
Title:
Apoptosis, intrinsic radiosensitivity and prediction of radiotherapy response in cervical carcinoma.
Authors:
Levine, Edward; Renehan, Andrew G ( 0000-0003-4309-4396 ) ; Gossiel, R; Davidson, Susan E; Roberts, Stephen A; Chadwick, Caroline A; Wilks, Deepti P; Potten, Christopher S; Hendry, Jolyon H; Hunter, Robin D; West, Catharine M L
Abstract:
Apoptosis is an important mechanism of cell death in tumours and it is seen both prior to and following radiotherapy. In this study patients with proven carcinoma of the cervix had measurement made of the percentage of apoptotic cells (apoptotic index or AI) in pre-therapy biopsies. Measurements of intrinsic radiosensitivity (SF2), already shown to be a predictor of outcome, had previously been made on the same pre-therapy biopsies. Mitotic index (MI) and Ki-67 antigen staining were also recorded as markers for proliferation. Patients were divided into those with an AI above or below the median and in general increasing apoptosis was associated with poor prognosis. The 5-year survival rate for tumours with an AI below the median was 79% and was significantly greater than the rate of 47% for those with an AI above the median (p = 0.003). There was also a significantly increased 5-year local recurrence-free rate for patients with an AI below the median compared with those with an AI above the median (79 versus 61%, p = 0.012). In addition, AI and SF2 acted as independent prognostic indicators. Patients with both an SF2 and AI value above the median did badly (25% 5-year survival, 46% local control) compared with those with an SF2 and AI below the median (80% 5-year survival, 100% local control). Apoptosis showed correlation with MI (n = 66, r = 0.34, p = 0.002) and cell staining for the Ki-67 antigen (n = 57, r = 0.25, p = 0.03), but neither MI nor Ki-67 were related to patient outcome. This suggests that while apoptosis may be a reflection of tumour proliferation this cannot in itself explain the ability of apoptosis to predict clinical outcome for this series of patients. The study raises the possibility of AI and SF2 being used together as predictors of tumour response to radiotherapy.
Affiliation:
Department of Experimental Radiation Oncology, Paterson Institute For Cancer Research, Manchester, UK.
Citation:
Apoptosis, intrinsic radiosensitivity and prediction of radiotherapy response in cervical carcinoma. 1995, 37 (1):1-9 Radiother Oncol
Journal:
Radiotherapy and Oncology
Issue Date:
Oct-1995
URI:
http://hdl.handle.net/10541/99306
DOI:
10.1016/0167-8140(95)01622-N
PubMed ID:
8539450
Type:
Article
Language:
en
ISSN:
0167-8140
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorLevine, Edwarden
dc.contributor.authorRenehan, Andrew Gen
dc.contributor.authorGossiel, Ren
dc.contributor.authorDavidson, Susan Een
dc.contributor.authorRoberts, Stephen Aen
dc.contributor.authorChadwick, Caroline Aen
dc.contributor.authorWilks, Deepti Pen
dc.contributor.authorPotten, Christopher Sen
dc.contributor.authorHendry, Jolyon Hen
dc.contributor.authorHunter, Robin Den
dc.contributor.authorWest, Catharine M Len
dc.date.accessioned2010-05-19T13:50:04Z-
dc.date.available2010-05-19T13:50:04Z-
dc.date.issued1995-10-
dc.identifier.citationApoptosis, intrinsic radiosensitivity and prediction of radiotherapy response in cervical carcinoma. 1995, 37 (1):1-9 Radiother Oncolen
dc.identifier.issn0167-8140-
dc.identifier.pmid8539450-
dc.identifier.doi10.1016/0167-8140(95)01622-N-
dc.identifier.urihttp://hdl.handle.net/10541/99306-
dc.description.abstractApoptosis is an important mechanism of cell death in tumours and it is seen both prior to and following radiotherapy. In this study patients with proven carcinoma of the cervix had measurement made of the percentage of apoptotic cells (apoptotic index or AI) in pre-therapy biopsies. Measurements of intrinsic radiosensitivity (SF2), already shown to be a predictor of outcome, had previously been made on the same pre-therapy biopsies. Mitotic index (MI) and Ki-67 antigen staining were also recorded as markers for proliferation. Patients were divided into those with an AI above or below the median and in general increasing apoptosis was associated with poor prognosis. The 5-year survival rate for tumours with an AI below the median was 79% and was significantly greater than the rate of 47% for those with an AI above the median (p = 0.003). There was also a significantly increased 5-year local recurrence-free rate for patients with an AI below the median compared with those with an AI above the median (79 versus 61%, p = 0.012). In addition, AI and SF2 acted as independent prognostic indicators. Patients with both an SF2 and AI value above the median did badly (25% 5-year survival, 46% local control) compared with those with an SF2 and AI below the median (80% 5-year survival, 100% local control). Apoptosis showed correlation with MI (n = 66, r = 0.34, p = 0.002) and cell staining for the Ki-67 antigen (n = 57, r = 0.25, p = 0.03), but neither MI nor Ki-67 were related to patient outcome. This suggests that while apoptosis may be a reflection of tumour proliferation this cannot in itself explain the ability of apoptosis to predict clinical outcome for this series of patients. The study raises the possibility of AI and SF2 being used together as predictors of tumour response to radiotherapy.en
dc.language.isoenen
dc.subjectCancer Proteinsen
dc.subjectCancer Recurrenceen
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshApoptosis-
dc.subject.meshCarcinoma, Squamous Cell-
dc.subject.meshCell Division-
dc.subject.meshDisease-Free Survival-
dc.subject.meshFemale-
dc.subject.meshFollow-Up Studies-
dc.subject.meshForecasting-
dc.subject.meshHumans-
dc.subject.meshKi-67 Antigen-
dc.subject.meshMiddle Aged-
dc.subject.meshMitosis-
dc.subject.meshMultivariate Analysis-
dc.subject.meshNeoplasm Proteins-
dc.subject.meshNeoplasm Recurrence, Local-
dc.subject.meshNuclear Proteins-
dc.subject.meshPrognosis-
dc.subject.meshRadiation Tolerance-
dc.subject.meshRadiotherapy Dosage-
dc.subject.meshSurvival Rate-
dc.subject.meshTreatment Outcome-
dc.subject.meshUterine Cervical Neoplasms-
dc.titleApoptosis, intrinsic radiosensitivity and prediction of radiotherapy response in cervical carcinoma.en
dc.typeArticleen
dc.contributor.departmentDepartment of Experimental Radiation Oncology, Paterson Institute For Cancer Research, Manchester, UK.en
dc.identifier.journalRadiotherapy and Oncologyen

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