Survival and quality of life of paediatric intracranial germ cell tumour patients treated at the Christie Hospital, 1972-1993.

2.50
Hdl Handle:
http://hdl.handle.net/10541/99277
Title:
Survival and quality of life of paediatric intracranial germ cell tumour patients treated at the Christie Hospital, 1972-1993.
Authors:
Kiltie, Anne E; Gattamaneni, Rao
Abstract:
From 1972 to 1993, 25 patients under 16 years old were treated at the Christie Hospital for intracranial germ cell tumours (ICGCTs). A retrospective analysis of the case notes was undertaken. The cases comprised 10 germinomas, nine non-germinomatous germ cell tumours (NGGCTs), and six cases with no histology. Ten patients had either complete or incomplete removal of the tumour. All patients received radiotherapy (20 patients received craniospinal irradiation [CSI]). Thirteen patients received chemotherapy at presentation (six platinum-based). All marker-negative pure germinomas treated with CSI survived. The actuarial 5-year survival for NGGCTs was 44%. Although CSI resulted in spine shortening, the overall effect on growth was not marked and the neuropsychologic sequelae were minimal with good overall functional results.
Affiliation:
Department of Clinical Oncology, Christie Hospital NHS Trust, Manchester, United Kingdom.
Citation:
Survival and quality of life of paediatric intracranial germ cell tumour patients treated at the Christie Hospital, 1972-1993. 1995, 25 (6):450-6 Med. Pediatr. Oncol.
Journal:
Medical and Pediatric Oncology
Issue Date:
Dec-1995
URI:
http://hdl.handle.net/10541/99277
DOI:
10.1002/mpo.2950250606
PubMed ID:
7565307
Type:
Article
Language:
en
ISSN:
0098-1532
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorKiltie, Anne Een
dc.contributor.authorGattamaneni, Raoen
dc.date.accessioned2010-05-19T11:26:50Z-
dc.date.available2010-05-19T11:26:50Z-
dc.date.issued1995-12-
dc.identifier.citationSurvival and quality of life of paediatric intracranial germ cell tumour patients treated at the Christie Hospital, 1972-1993. 1995, 25 (6):450-6 Med. Pediatr. Oncol.en
dc.identifier.issn0098-1532-
dc.identifier.pmid7565307-
dc.identifier.doi10.1002/mpo.2950250606-
dc.identifier.urihttp://hdl.handle.net/10541/99277-
dc.description.abstractFrom 1972 to 1993, 25 patients under 16 years old were treated at the Christie Hospital for intracranial germ cell tumours (ICGCTs). A retrospective analysis of the case notes was undertaken. The cases comprised 10 germinomas, nine non-germinomatous germ cell tumours (NGGCTs), and six cases with no histology. Ten patients had either complete or incomplete removal of the tumour. All patients received radiotherapy (20 patients received craniospinal irradiation [CSI]). Thirteen patients received chemotherapy at presentation (six platinum-based). All marker-negative pure germinomas treated with CSI survived. The actuarial 5-year survival for NGGCTs was 44%. Although CSI resulted in spine shortening, the overall effect on growth was not marked and the neuropsychologic sequelae were minimal with good overall functional results.en
dc.language.isoenen
dc.subjectBrain Canceren
dc.subject.meshAdolescent-
dc.subject.meshBrain Neoplasms-
dc.subject.meshChild-
dc.subject.meshChild, Preschool-
dc.subject.meshFemale-
dc.subject.meshGerminoma-
dc.subject.meshHumans-
dc.subject.meshMale-
dc.subject.meshQuality of Life-
dc.subject.meshRetrospective Studies-
dc.subject.meshSurvival Rate-
dc.titleSurvival and quality of life of paediatric intracranial germ cell tumour patients treated at the Christie Hospital, 1972-1993.en
dc.typeArticleen
dc.contributor.departmentDepartment of Clinical Oncology, Christie Hospital NHS Trust, Manchester, United Kingdom.en
dc.identifier.journalMedical and Pediatric Oncologyen

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