Preliminary evidence of an association between HLA-DPB1*0201 and childhood common acute lymphoblastic leukaemia supports an infectious aetiology.

2.50
Hdl Handle:
http://hdl.handle.net/10541/99249
Title:
Preliminary evidence of an association between HLA-DPB1*0201 and childhood common acute lymphoblastic leukaemia supports an infectious aetiology.
Authors:
Taylor, G M; Robinson, M D; Binchy, A; Birch, Jillian M; Stevens, R F; Jones, P M; Carr, T; Dearden, S; Gokhale, D A
Abstract:
It has been suggested that childhood leukaemia may be the abnormal outcome of a common infection. Rare events caused by common environmental events such as infections are likely to be influenced by host genetic susceptibility. We have therefore investigated whether immunogenetic susceptibility contributes to the risk of childhood common ALL (c-ALL). In this preliminary study, we report that children with c-ALL (n = 63) carry the HLA-DPB1 locus allele *0201 twice and nearly three times more frequently than adult (n = 92; relative risk (RR) = 2.9, P < 0.05) or infant controls (n = 82; RR = 2.1). Moreover, children with c-ALL are 3-4 times more likely than controls to be heterozygous for DPB1*0201/*0301, /*0401 and /*0402 (RRadult controls = 3.9; RRinfant controls = 2.8). These results suggest that HLA-DPB1*0201 either alone or with other DPB1 alleles contributes to the risk of childhood c-ALL, possibly by increasing susceptibility to an infectious agent.
Affiliation:
Immunogenetics Laboratory, St Mary's Hospital, Manchester, UK.
Citation:
Preliminary evidence of an association between HLA-DPB1*0201 and childhood common acute lymphoblastic leukaemia supports an infectious aetiology. 1995, 9 (3):440-3 Leukemia
Journal:
Leukemia
Issue Date:
Mar-1995
URI:
http://hdl.handle.net/10541/99249
PubMed ID:
7885043
Type:
Article
Language:
en
ISSN:
0887-6924
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorTaylor, G Men
dc.contributor.authorRobinson, M Den
dc.contributor.authorBinchy, Aen
dc.contributor.authorBirch, Jillian Men
dc.contributor.authorStevens, R Fen
dc.contributor.authorJones, P Men
dc.contributor.authorCarr, Ten
dc.contributor.authorDearden, Sen
dc.contributor.authorGokhale, D Aen
dc.date.accessioned2010-05-19T11:10:39Z-
dc.date.available2010-05-19T11:10:39Z-
dc.date.issued1995-03-
dc.identifier.citationPreliminary evidence of an association between HLA-DPB1*0201 and childhood common acute lymphoblastic leukaemia supports an infectious aetiology. 1995, 9 (3):440-3 Leukemiaen
dc.identifier.issn0887-6924-
dc.identifier.pmid7885043-
dc.identifier.urihttp://hdl.handle.net/10541/99249-
dc.description.abstractIt has been suggested that childhood leukaemia may be the abnormal outcome of a common infection. Rare events caused by common environmental events such as infections are likely to be influenced by host genetic susceptibility. We have therefore investigated whether immunogenetic susceptibility contributes to the risk of childhood common ALL (c-ALL). In this preliminary study, we report that children with c-ALL (n = 63) carry the HLA-DPB1 locus allele *0201 twice and nearly three times more frequently than adult (n = 92; relative risk (RR) = 2.9, P < 0.05) or infant controls (n = 82; RR = 2.1). Moreover, children with c-ALL are 3-4 times more likely than controls to be heterozygous for DPB1*0201/*0301, /*0401 and /*0402 (RRadult controls = 3.9; RRinfant controls = 2.8). These results suggest that HLA-DPB1*0201 either alone or with other DPB1 alleles contributes to the risk of childhood c-ALL, possibly by increasing susceptibility to an infectious agent.en
dc.language.isoenen
dc.subjectPrecursor B-Cell Lymphoblastic Leukaemia-Lymphomaen
dc.subject.meshAdolescent-
dc.subject.meshAlleles-
dc.subject.meshChild-
dc.subject.meshChild, Preschool-
dc.subject.meshDisease Susceptibility-
dc.subject.meshFemale-
dc.subject.meshGenetic Predisposition to Disease-
dc.subject.meshGenotype-
dc.subject.meshHLA-DP Antigens-
dc.subject.meshHumans-
dc.subject.meshInfant-
dc.subject.meshInfection-
dc.subject.meshMale-
dc.subject.meshPolymerase Chain Reaction-
dc.subject.meshPrecursor B-Cell Lymphoblastic Leukemia-Lymphoma-
dc.titlePreliminary evidence of an association between HLA-DPB1*0201 and childhood common acute lymphoblastic leukaemia supports an infectious aetiology.en
dc.typeArticleen
dc.contributor.departmentImmunogenetics Laboratory, St Mary's Hospital, Manchester, UK.en
dc.identifier.journalLeukemiaen

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