2.50
Hdl Handle:
http://hdl.handle.net/10541/99091
Title:
Inflammatory pseudotumour of lymph nodes.
Authors:
New, N E; Bishop, P W; Stewart, M; Banerjee, Saumitra S; Harris, Martin
Abstract:
AIM: To describe the clinical, histological and immunohistochemical features in four cases of an uncommon benign lymph node lesion which may mimic a neoplastic process. METHODS: Four cases of inflammatory pseudotumour of lymph nodes were studied using conventional staining (haematoxylin and eosin, PAS, Gordon and Sweets reticulin stain, and the Ziehl-Neelsen stain) and with immunohistochemical techniques using a variety of antibodies (CD3, L26, CD15, CD21, CD30, KP1, MAC 387, vimentin, alpha SMA, HHF-35, D33, CD34, and S100). RESULTS: The lesion comprises a proliferation of spindle cells expanding the connective tissue framework of lymph nodes and is associated with a plasma cell and small lymphocyte infiltrate. There are variable numbers of macrophages, neutrophils and eosinophils, and varying degrees of fibrosis. Vascular changes are common but vary in degree and type. CONCLUSIONS: Inflammatory pseudotumour of lymph nodes is an uncommon benign reaction pattern which may be misdiagnosed as a neoplastic or even a malignant process. Increased awareness of its histological features should help prevent such misdiagnoses.
Affiliation:
Department of Pathology, Christie Hospital NHS Trust, Withington, Manchester.
Citation:
Inflammatory pseudotumour of lymph nodes. 1995, 48 (1):37-40 J. Clin. Pathol.
Journal:
Journal of Clinical Pathology
Issue Date:
Jan-1995
URI:
http://hdl.handle.net/10541/99091
DOI:
10.1136/jcp.48.1.37
PubMed ID:
7706516
Type:
Article
Language:
en
ISSN:
0021-9746
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorNew, N Een
dc.contributor.authorBishop, P Wen
dc.contributor.authorStewart, Men
dc.contributor.authorBanerjee, Saumitra Sen
dc.contributor.authorHarris, Martinen
dc.date.accessioned2010-05-18T12:05:49Z-
dc.date.available2010-05-18T12:05:49Z-
dc.date.issued1995-01-
dc.identifier.citationInflammatory pseudotumour of lymph nodes. 1995, 48 (1):37-40 J. Clin. Pathol.en
dc.identifier.issn0021-9746-
dc.identifier.pmid7706516-
dc.identifier.doi10.1136/jcp.48.1.37-
dc.identifier.urihttp://hdl.handle.net/10541/99091-
dc.description.abstractAIM: To describe the clinical, histological and immunohistochemical features in four cases of an uncommon benign lymph node lesion which may mimic a neoplastic process. METHODS: Four cases of inflammatory pseudotumour of lymph nodes were studied using conventional staining (haematoxylin and eosin, PAS, Gordon and Sweets reticulin stain, and the Ziehl-Neelsen stain) and with immunohistochemical techniques using a variety of antibodies (CD3, L26, CD15, CD21, CD30, KP1, MAC 387, vimentin, alpha SMA, HHF-35, D33, CD34, and S100). RESULTS: The lesion comprises a proliferation of spindle cells expanding the connective tissue framework of lymph nodes and is associated with a plasma cell and small lymphocyte infiltrate. There are variable numbers of macrophages, neutrophils and eosinophils, and varying degrees of fibrosis. Vascular changes are common but vary in degree and type. CONCLUSIONS: Inflammatory pseudotumour of lymph nodes is an uncommon benign reaction pattern which may be misdiagnosed as a neoplastic or even a malignant process. Increased awareness of its histological features should help prevent such misdiagnoses.en
dc.language.isoenen
dc.subject.meshAdult-
dc.subject.meshDiagnosis, Differential-
dc.subject.meshFemale-
dc.subject.meshGranuloma, Plasma Cell-
dc.subject.meshHumans-
dc.subject.meshImmune Sera-
dc.subject.meshLymphatic Diseases-
dc.subject.meshLymphocytes-
dc.subject.meshLymphoma-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshPlasma Cells-
dc.subject.meshRetrospective Studies-
dc.titleInflammatory pseudotumour of lymph nodes.en
dc.typeArticleen
dc.contributor.departmentDepartment of Pathology, Christie Hospital NHS Trust, Withington, Manchester.en
dc.identifier.journalJournal of Clinical Pathologyen

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