Effect of growth hormone replacement on bone mass in adults with adult onset growth hormone deficiency.

2.50
Hdl Handle:
http://hdl.handle.net/10541/98400
Title:
Effect of growth hormone replacement on bone mass in adults with adult onset growth hormone deficiency.
Authors:
Holmes, Sarah J; Whitehouse, R W; Swindell, Ric; Economou, G; Adams, J E; Shalet, Stephen M
Abstract:
OBJECTIVE: Previous studies of the effect of GH replacement on bone mass in adults with GH deficiency have produced conflicting results. We have studied the effect of 6 and 12 months of GH replacement on bone mass in adults with adult onset GH deficiency. DESIGN: Double blind placebo controlled study of GH replacement (0.125 IU/kg/week for the first month and 0.25 IU/kg/week thereafter) for 6 months and an open study for a further 6 or 12 months. PATIENTS: Twenty-two adults (10 men, 12 women), aged 41.5 +/- 2.1 years (mean +/- SE, range 23.6-59.5), with adult onset GH deficiency. MEASUREMENTS: Single-energy quantitative computed tomography was used to measure vertebral trabecular bone mineral density (BMD), single-photon absorptiometry (SPA) was used to measure forearm cortical and integral bone mineral content and BMD and dual-energy X-ray absorptiometry (DXA) was used to measure lumbar spine, femoral neck, trochanteric and Ward's triangle integral BMD. RESULTS: After 6 months of GH replacement (n = 21) there was a significant decrease in forearm cortical BMD (SPA: median change -0.009 g/cm2, P = 0.01), forearm integral BMD (SPA: median change -0.016 g/cm2, P = 0.03), lumbar spine BMD (DXA: median change -0.22 g/cm2; P = 0.003) and femoral neck BMD (DXA: median change -0.029 g/cm2, P = 0.006). After 12 months of GH replacement (n = 13) there was a significant decrease in lumbar spine BMD (DXA: median change -0.035 g/cm2, P = 0.002) from baseline. There was no significant increase in bone mass at any site after 6 or 12 months of GH replacement. Change in bone mass was not influenced by sex of the patient or by presence or absence of additional pituitary hormone deficiencies. CONCLUSION: The response of bone mass to 6 and 12 months of GH replacement in adults with adult onset GH deficiency is disappointing. Longer-term studies are required to determine whether prolonged GH replacement has a beneficial effect on bone mass.
Affiliation:
Department of Endocrinology, Christie Hospital NHS Trust, Manchester, UK.
Citation:
Effect of growth hormone replacement on bone mass in adults with adult onset growth hormone deficiency. 1995, 42 (6):627-33 Clin. Endocrinol
Journal:
Clinical Endocrinology
Issue Date:
Jun-1995
URI:
http://hdl.handle.net/10541/98400
DOI:
10.1111/j.1365-2265.1995.tb02690.x
PubMed ID:
7634504
Type:
Article
Language:
en
ISSN:
0300-0664
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorHolmes, Sarah Jen
dc.contributor.authorWhitehouse, R Wen
dc.contributor.authorSwindell, Ricen
dc.contributor.authorEconomou, Gen
dc.contributor.authorAdams, J Een
dc.contributor.authorShalet, Stephen Men
dc.date.accessioned2010-05-10T16:25:22Z-
dc.date.available2010-05-10T16:25:22Z-
dc.date.issued1995-06-
dc.identifier.citationEffect of growth hormone replacement on bone mass in adults with adult onset growth hormone deficiency. 1995, 42 (6):627-33 Clin. Endocrinolen
dc.identifier.issn0300-0664-
dc.identifier.pmid7634504-
dc.identifier.doi10.1111/j.1365-2265.1995.tb02690.x-
dc.identifier.urihttp://hdl.handle.net/10541/98400-
dc.description.abstractOBJECTIVE: Previous studies of the effect of GH replacement on bone mass in adults with GH deficiency have produced conflicting results. We have studied the effect of 6 and 12 months of GH replacement on bone mass in adults with adult onset GH deficiency. DESIGN: Double blind placebo controlled study of GH replacement (0.125 IU/kg/week for the first month and 0.25 IU/kg/week thereafter) for 6 months and an open study for a further 6 or 12 months. PATIENTS: Twenty-two adults (10 men, 12 women), aged 41.5 +/- 2.1 years (mean +/- SE, range 23.6-59.5), with adult onset GH deficiency. MEASUREMENTS: Single-energy quantitative computed tomography was used to measure vertebral trabecular bone mineral density (BMD), single-photon absorptiometry (SPA) was used to measure forearm cortical and integral bone mineral content and BMD and dual-energy X-ray absorptiometry (DXA) was used to measure lumbar spine, femoral neck, trochanteric and Ward's triangle integral BMD. RESULTS: After 6 months of GH replacement (n = 21) there was a significant decrease in forearm cortical BMD (SPA: median change -0.009 g/cm2, P = 0.01), forearm integral BMD (SPA: median change -0.016 g/cm2, P = 0.03), lumbar spine BMD (DXA: median change -0.22 g/cm2; P = 0.003) and femoral neck BMD (DXA: median change -0.029 g/cm2, P = 0.006). After 12 months of GH replacement (n = 13) there was a significant decrease in lumbar spine BMD (DXA: median change -0.035 g/cm2, P = 0.002) from baseline. There was no significant increase in bone mass at any site after 6 or 12 months of GH replacement. Change in bone mass was not influenced by sex of the patient or by presence or absence of additional pituitary hormone deficiencies. CONCLUSION: The response of bone mass to 6 and 12 months of GH replacement in adults with adult onset GH deficiency is disappointing. Longer-term studies are required to determine whether prolonged GH replacement has a beneficial effect on bone mass.en
dc.language.isoenen
dc.subject.meshAdult-
dc.subject.meshBone Density-
dc.subject.meshDouble-Blind Method-
dc.subject.meshFemale-
dc.subject.meshFemur Neck-
dc.subject.meshForearm-
dc.subject.meshGrowth Hormone-
dc.subject.meshHumans-
dc.subject.meshLumbar Vertebrae-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshTime Factors-
dc.titleEffect of growth hormone replacement on bone mass in adults with adult onset growth hormone deficiency.en
dc.typeArticleen
dc.contributor.departmentDepartment of Endocrinology, Christie Hospital NHS Trust, Manchester, UK.en
dc.identifier.journalClinical Endocrinologyen

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