Radiotherapy in the treatment of low-grade astrocytomas. II. The physical and cognitive sequelae.

2.50
Hdl Handle:
http://hdl.handle.net/10541/98384
Title:
Radiotherapy in the treatment of low-grade astrocytomas. II. The physical and cognitive sequelae.
Authors:
Chadderton, R D; West, C G; Schuller, S; Quirke, D C; Gattamaneni, Rao; Taylor, R
Abstract:
The purpose of the present study was to define the late effects, both physical and psychological, of treating low-grade astrocytomas with radiotherapy. Fifty patients, half of whom received radiotherapy, underwent an assessment of neurological and neuropsychological function. There was no difference in neurological function between the two groups. The radiotherapy recipients, including those with cerebellar tumours, performed significantly worse on measures of intelligence and information processing. In addition, there was a greater incidence of special education needs in the irradiated group. We conclude that children with low-grade astrocytomas who receive radiotherapy have no greater neurological deficit but that the use of radiotherapy carries a penalty in terms of long-term cognitive function and confirmed the findings of many previous reports that supratentorial irradiation is detrimental. More surprisingly, it has been demonstrated that local field irradiation to the posterior fossa can also produce significant cognitive impairment.
Affiliation:
Department of Neurological Surgery, Royal Manchester Children's Hospital, UK.
Citation:
Radiotherapy in the treatment of low-grade astrocytomas. II. The physical and cognitive sequelae. 1995, 11 (8):443-8 Childs Nerv Syst
Journal:
Child's Nervous System
Issue Date:
Aug-1995
URI:
http://hdl.handle.net/10541/98384
DOI:
10.1007/BF00334961
PubMed ID:
7585679
Type:
Article
Language:
en
ISSN:
0256-7040
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorChadderton, R Den
dc.contributor.authorWest, C Gen
dc.contributor.authorSchuller, Sen
dc.contributor.authorQuirke, D Cen
dc.contributor.authorGattamaneni, Raoen
dc.contributor.authorTaylor, Ren
dc.date.accessioned2010-05-10T16:14:50Z-
dc.date.available2010-05-10T16:14:50Z-
dc.date.issued1995-08-
dc.identifier.citationRadiotherapy in the treatment of low-grade astrocytomas. II. The physical and cognitive sequelae. 1995, 11 (8):443-8 Childs Nerv Systen
dc.identifier.issn0256-7040-
dc.identifier.pmid7585679-
dc.identifier.doi10.1007/BF00334961-
dc.identifier.urihttp://hdl.handle.net/10541/98384-
dc.description.abstractThe purpose of the present study was to define the late effects, both physical and psychological, of treating low-grade astrocytomas with radiotherapy. Fifty patients, half of whom received radiotherapy, underwent an assessment of neurological and neuropsychological function. There was no difference in neurological function between the two groups. The radiotherapy recipients, including those with cerebellar tumours, performed significantly worse on measures of intelligence and information processing. In addition, there was a greater incidence of special education needs in the irradiated group. We conclude that children with low-grade astrocytomas who receive radiotherapy have no greater neurological deficit but that the use of radiotherapy carries a penalty in terms of long-term cognitive function and confirmed the findings of many previous reports that supratentorial irradiation is detrimental. More surprisingly, it has been demonstrated that local field irradiation to the posterior fossa can also produce significant cognitive impairment.en
dc.language.isoenen
dc.subjectBrain Canceren
dc.subject.meshAdolescent-
dc.subject.meshAstrocytoma-
dc.subject.meshBrain-
dc.subject.meshBrain Neoplasms-
dc.subject.meshChild-
dc.subject.meshChild, Preschool-
dc.subject.meshCognition Disorders-
dc.subject.meshCombined Modality Therapy-
dc.subject.meshCranial Irradiation-
dc.subject.meshFemale-
dc.subject.meshFollow-Up Studies-
dc.subject.meshHumans-
dc.subject.meshInfant-
dc.subject.meshIntelligence-
dc.subject.meshMale-
dc.subject.meshMental Recall-
dc.subject.meshNeurologic Examination-
dc.subject.meshNeuropsychological Tests-
dc.subject.meshRadiation Injuries-
dc.subject.meshRadiotherapy, Adjuvant-
dc.subject.meshReading-
dc.titleRadiotherapy in the treatment of low-grade astrocytomas. II. The physical and cognitive sequelae.en
dc.typeArticleen
dc.contributor.departmentDepartment of Neurological Surgery, Royal Manchester Children's Hospital, UK.en
dc.identifier.journalChild's Nervous Systemen

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