Degree of activation of the pituitary-testicular axis in early pubertal boys with constitutional delay of growth and puberty determines the growth response to treatment with testosterone or oxandrolone.

2.50
Hdl Handle:
http://hdl.handle.net/10541/98100
Title:
Degree of activation of the pituitary-testicular axis in early pubertal boys with constitutional delay of growth and puberty determines the growth response to treatment with testosterone or oxandrolone.
Authors:
Crowne, Elizabeth C; Wallace, W Hamish B; Moore, C; Mitchell, R; Robertson, W R; Shalet, Stephen M
Abstract:
Early pubertal boys (testicular volume, 4-6 mL) with constitutionally delayed growth and puberty were randomized to 3 months of treatment after a baseline 12-h overnight hormone profile: group 1 (n = 5), daily placebo; group 2 (n = 5), 2.5 mg oxandrolone daily; or group 3 (n = 6), 50-mg testosterone monthly im injections. LH and GH profiles (15-min samples) were analyzed by peak detection (Pulsar), Fourier transformation, and autocorrelation. FSH and testosterone levels were measured hourly, and insulin, sex hormone-binding globulin, insulin-like growth factor-I, and insulin-like growth factor-binding protein-3 levels were determined at 0800 h. Multiple regression was used to analyze the response to treatment (growth) with respect to baseline features. Endocrine variability was marked. Profiles ranged from unreactive to well established LH pulsatility and adult testosterone levels. The areas under the curve (AUC) for LH, FSH, and testosterone ranged 10-fold (4.4-46.3 IU/L.h), 8-fold (7.9-63.4 IU/L.h), and 45-fold (3.6-161.7 nmol/L.h), respectively. The growth response was individually varied, but significantly increased 0-6 months in the active treatment groups. Age, testicular volume, and LH AUC interacted significantly (r2 = 0.95; P < 0.05). Allowance for these produced a highly significant treatment effect (P = 0.006). Age, testicular volume, LH AUC, and testosterone AUC, but not treatment, significantly increased growth by 0-12 months (r2 = 0.88; P < 0.05). We demonstrate a spectrum of activation of the reproductive axis despite tight clinical staging. This, and not GH status at treatment commencement, influenced the growth response.
Affiliation:
Department of Endocrinology, Christie Hospital Trust, Manchester, United Kingdom.
Citation:
Degree of activation of the pituitary-testicular axis in early pubertal boys with constitutional delay of growth and puberty determines the growth response to treatment with testosterone or oxandrolone. 1995, 80 (6):1869-75 J. Clin. Endocrinol. Metab.
Journal:
The Journal of Clinical Endocrinology and Metabolism
Issue Date:
Jun-1995
URI:
http://hdl.handle.net/10541/98100
DOI:
10.1210/jc.80.6.1869
PubMed ID:
7775634
Type:
Article
Language:
en
ISSN:
0021-972X
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorCrowne, Elizabeth Cen
dc.contributor.authorWallace, W Hamish Ben
dc.contributor.authorMoore, Cen
dc.contributor.authorMitchell, Ren
dc.contributor.authorRobertson, W Ren
dc.contributor.authorShalet, Stephen Men
dc.date.accessioned2010-05-06T16:26:14Z-
dc.date.available2010-05-06T16:26:14Z-
dc.date.issued1995-06-
dc.identifier.citationDegree of activation of the pituitary-testicular axis in early pubertal boys with constitutional delay of growth and puberty determines the growth response to treatment with testosterone or oxandrolone. 1995, 80 (6):1869-75 J. Clin. Endocrinol. Metab.en
dc.identifier.issn0021-972X-
dc.identifier.pmid7775634-
dc.identifier.doi10.1210/jc.80.6.1869-
dc.identifier.urihttp://hdl.handle.net/10541/98100-
dc.description.abstractEarly pubertal boys (testicular volume, 4-6 mL) with constitutionally delayed growth and puberty were randomized to 3 months of treatment after a baseline 12-h overnight hormone profile: group 1 (n = 5), daily placebo; group 2 (n = 5), 2.5 mg oxandrolone daily; or group 3 (n = 6), 50-mg testosterone monthly im injections. LH and GH profiles (15-min samples) were analyzed by peak detection (Pulsar), Fourier transformation, and autocorrelation. FSH and testosterone levels were measured hourly, and insulin, sex hormone-binding globulin, insulin-like growth factor-I, and insulin-like growth factor-binding protein-3 levels were determined at 0800 h. Multiple regression was used to analyze the response to treatment (growth) with respect to baseline features. Endocrine variability was marked. Profiles ranged from unreactive to well established LH pulsatility and adult testosterone levels. The areas under the curve (AUC) for LH, FSH, and testosterone ranged 10-fold (4.4-46.3 IU/L.h), 8-fold (7.9-63.4 IU/L.h), and 45-fold (3.6-161.7 nmol/L.h), respectively. The growth response was individually varied, but significantly increased 0-6 months in the active treatment groups. Age, testicular volume, and LH AUC interacted significantly (r2 = 0.95; P < 0.05). Allowance for these produced a highly significant treatment effect (P = 0.006). Age, testicular volume, LH AUC, and testosterone AUC, but not treatment, significantly increased growth by 0-12 months (r2 = 0.88; P < 0.05). We demonstrate a spectrum of activation of the reproductive axis despite tight clinical staging. This, and not GH status at treatment commencement, influenced the growth response.en
dc.language.isoenen
dc.subject.meshAdolescent-
dc.subject.meshBody Height-
dc.subject.meshFollicle Stimulating Hormone-
dc.subject.meshFourier Analysis-
dc.subject.meshGrowth Hormone-
dc.subject.meshHumans-
dc.subject.meshLuteinizing Hormone-
dc.subject.meshMale-
dc.subject.meshOxandrolone-
dc.subject.meshPeriodicity-
dc.subject.meshPituitary Gland-
dc.subject.meshPlacebos-
dc.subject.meshProspective Studies-
dc.subject.meshPuberty-
dc.subject.meshPuberty, Delayed-
dc.subject.meshRegression Analysis-
dc.subject.meshTestis-
dc.subject.meshTestosterone-
dc.titleDegree of activation of the pituitary-testicular axis in early pubertal boys with constitutional delay of growth and puberty determines the growth response to treatment with testosterone or oxandrolone.en
dc.typeArticleen
dc.contributor.departmentDepartment of Endocrinology, Christie Hospital Trust, Manchester, United Kingdom.en
dc.identifier.journalThe Journal of Clinical Endocrinology and Metabolismen

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