2.50
Hdl Handle:
http://hdl.handle.net/10541/97962
Title:
Apoptosis induced by high- and low-LET radiations.
Authors:
Hendry, Jolyon H; Potten, Christopher S; Merritt, Anita J
Abstract:
Cell death after irradiation occurs by apoptosis in certain cell populations in tissues. The phenomenon also occurs after high linear energy transfer (LET) irradiation, and the relative biological effectiveness (RBE) is 3 to 4 (with respect to low-LET radiation and apoptosis in intestinal crypts) for neutrons with energies of 14 MeV and up to 600 MeV. It is thought that p53 plays a role in the phenomenon, as radiation-induced apoptosis is not observed in p53-null animals.
Affiliation:
CRC Department of Experimental Radiation Oncology, Paterson Institute for Cancer Research, Christie Hospital (NHS) Trust, Manchester, UK.
Citation:
Apoptosis induced by high- and low-LET radiations. 1995, 34 (1):59-62 Radiat Environ Biophys
Journal:
Radiation and Environmental Biophysics
Issue Date:
Mar-1995
URI:
http://hdl.handle.net/10541/97962
DOI:
10.1007/BF01210548
PubMed ID:
7604163
Type:
Article
Language:
en
ISSN:
0301-634X
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorHendry, Jolyon Hen
dc.contributor.authorPotten, Christopher Sen
dc.contributor.authorMerritt, Anita Jen
dc.date.accessioned2010-05-05T10:36:58Z-
dc.date.available2010-05-05T10:36:58Z-
dc.date.issued1995-03-
dc.identifier.citationApoptosis induced by high- and low-LET radiations. 1995, 34 (1):59-62 Radiat Environ Biophysen
dc.identifier.issn0301-634X-
dc.identifier.pmid7604163-
dc.identifier.doi10.1007/BF01210548-
dc.identifier.urihttp://hdl.handle.net/10541/97962-
dc.description.abstractCell death after irradiation occurs by apoptosis in certain cell populations in tissues. The phenomenon also occurs after high linear energy transfer (LET) irradiation, and the relative biological effectiveness (RBE) is 3 to 4 (with respect to low-LET radiation and apoptosis in intestinal crypts) for neutrons with energies of 14 MeV and up to 600 MeV. It is thought that p53 plays a role in the phenomenon, as radiation-induced apoptosis is not observed in p53-null animals.en
dc.language.isoenen
dc.subject.meshAnimals-
dc.subject.meshApoptosis-
dc.subject.meshDose-Response Relationship, Radiation-
dc.subject.meshGenes, p53-
dc.subject.meshHumans-
dc.subject.meshIntestine, Large-
dc.subject.meshIntestine, Small-
dc.subject.meshLinear Energy Transfer-
dc.subject.meshMice-
dc.subject.meshMice, Inbred Strains-
dc.subject.meshMice, Mutant Strains-
dc.titleApoptosis induced by high- and low-LET radiations.en
dc.typeArticleen
dc.contributor.departmentCRC Department of Experimental Radiation Oncology, Paterson Institute for Cancer Research, Christie Hospital (NHS) Trust, Manchester, UK.en
dc.identifier.journalRadiation and Environmental Biophysicsen

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